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Literature summary for 2.7.8.8 extracted from
- Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans (2019), J. Biol. Chem., 294, 2329-2339 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Cryptococcus neoformans | 5783 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cryptococcus neoformans | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CHO1 | - |
Cryptococcus neoformans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | expression of Cho1 in a Saccharomyces cerevisiae Cho1 deletion mutant rescues the mutant's growth defect in the absence of ethanolamine supplementation. An Saccharomyces cerevisiae Cho1 deletion mutant expressing Cryptococcus neoformans Cho1 has phosphatidylserine synthase activity. Expression of Cho1 in Cryptococcus neoformans is essential for mitochondrial function and cell viability. Its deficiency cannot be complemented by ethanolamine or choline supplementation | Cryptococcus neoformans |
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Release 2023.1 (January 2023)
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