Cloned (Comment) | Organism |
---|---|
gene PGS1, quantitative PCR enzyme expression analysis, recombinant overexpression of FLAG-tagged PGS1 in HEK-293 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-diacylglycerol + sn-glycerol 3-phosphate | Homo sapiens | - |
CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q32NB8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
testis | highest expression level of PGS1 mRNA | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-diacylglycerol + sn-glycerol 3-phosphate | - |
Homo sapiens | CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGP synthase 1 | - |
Homo sapiens |
PGS1 | - |
Homo sapiens |
phosphatidylglycerophosphate synthase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of phosphatidylglycerophosphate synthase 1, PGS1, increases the cellular contents of phosphatidylglycerol, cardiolipin, and phosphatidylcholine, and reduces that of phosphatidic acid. PGS1 overexpression also elevates the mitochondrial contents of cardiolipin and phosphatidylcholine, but has no effect on the number of mitochondria per cell | Homo sapiens |
metabolism | in mammalian cells, phosphatidylglycerol is produced from CDP-diacylglycerol (CDP-DAG) through two steps catalyzed by phosphatidylglycerophosphate (PGP) synthase and PGP phosphatase. CDP-DAG is formed from phosphatidic acid (PA) by the enzymes CDP-DAG synthase 1 and 2, which are integral membrane proteins located to mitochondria and endoplasmic reticulum. CDP-DAG is converted to PGP by the action of the mitochondrial enzyme PGP synthase 1 (PGS1) through the exchange of glycerol-3-phosphate (G3P) with CMP moiety of CDP-DAG. Phosphatidylglycerophosphate is rapidly dephosphorylated to generate phosphatidylglycerol | Homo sapiens |