Inhibitors | Comment | Organism | Structure |
---|---|---|---|
YW3548 | i.e. BE49385A, a terpenoid lactone, natural inhibitor of GPI biosynthesis, inhibits transfer of phosphoethanolamine to the first mannose in mammalian cells but only slightly affects the surface expression of GPI-anchored proteins. Biosynthesis of GPI in the Pig-n knockout cells s not affected by YW3548, and yeast overexpressing MCD4 is highly resistant to YW3548 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9R1S3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
F-9 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Pig-n | - |
Mus musculus |
Pign | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | in Pig-n knockout F9 embryonal carcinoma cells, the first mannose in the GPI precursors is not modified by phosphoethanolamine. Further biosynthetic steps continue with the addition of the third mannose and the terminal phosphoethanolamine. The surface expression of Thy-1 is only partially affected. An inhibitor of GPI biosynthesis, YW3548, inhibits transfer of phosphoethanolamine to the first mannose in mammalian cells but only slightly affects the surface expression of GPI-anchored proteins | Mus musculus |