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Literature summary for 2.7.7.84 extracted from

  • Leisching, G.; Ali, A.; Cole, V.; Baker, B.
    2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion (2020), Mol. Immunol., 118, 73-78 .
    View publication on PubMed
Search for more literature for 2.7.7.84

Protein Variants

Protein Variants Comment Organism
additional information OASL knockdown via siRNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 ATP Homo sapiens
-
 pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15646
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 ATP
-
 Homo sapiens pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
2'-5'-oligoadenylate synthetase-like
-
 Homo sapiens
OASL
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens pathogenic Mycobacterium tuberulosis infection induces OASL expression in THP1 macrophages 24 h post-infection up

General Information

General Information Comment Organism
malfunction the effects of OASL silencing on cytokine and chemokine (MCP-1) secretion in THP-1 macrophages can be summarised as follows: I. TNF-alpha and IL-1beta secretion is enhanced during mycobacterial infection in the presence of OASL, II. OASL enhances MCP-1 production in response to THP-1 infection by pathogenic mycobacteria only, and III. IL-10 production is unaffected by the presence/absence of OASL. Silencing of OASL promotes intracellular replication of pathogenic and non-pathogenic mycobacteria, OASL exerts a suppressive effect on intracellular mycobacterial replication Homo sapiens
physiological function human 2'-5'-oligoadenylate synthetase-like protein inhibits intracellular Mycobacterium tuberculosis replication and promotes proinflammatory cytokine secretion Homo sapiens