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Literature summary for 2.7.7.72 extracted from

  • Gruz, P.; Shimizu, M.; Pisani, F.M.; De Felice, M.; Kanke, Y.; Nohmi, T.
    Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus (2003), Nucleic Acids Res., 31, 4024-4030.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.72

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Saccharolobus solfataricus the specific recognition of deaminated bases by polymerase PolB1 may represent an initial step in their repair while polymerase PolY1 may be involved in damage tolerance at the replication fork. The deaminated bases can be introduced into DNA enzymatically, since both PolB1 and PolY1 are able to incorporate the aberrant DNA precursors dUTP and dITP diphosphate + DNAn+1
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 ?
deoxynucleoside triphosphate + DNAn Saccharolobus solfataricus P2 the specific recognition of deaminated bases by polymerase PolB1 may represent an initial step in their repair while polymerase PolY1 may be involved in damage tolerance at the replication fork. The deaminated bases can be introduced into DNA enzymatically, since both PolB1 and PolY1 are able to incorporate the aberrant DNA precursors dUTP and dITP diphosphate + DNAn+1
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 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
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Saccharolobus solfataricus P2
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Purification (Commentary)

Purification (Comment) Organism
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 Saccharolobus solfataricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn the specific recognition of deaminated bases by polymerase PolB1 may represent an initial step in their repair while polymerase PolY1 may be involved in damage tolerance at the replication fork. The deaminated bases can be introduced into DNA enzymatically, since both PolB1 and PolY1 are able to incorporate the aberrant DNA precursors dUTP and dITP Saccharolobus solfataricus diphosphate + DNAn+1
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 ?
deoxynucleoside triphosphate + DNAn specifically recognizes the presence of the deaminated bases hypoxanthine and uracil in the template by stalling DNA polymerization 3-4 bases upstream of these lesions and strongly associates with oligonucleotides containing them. PolB1 also stops at 8-oxoguanine and is unable to bypass an abasic site in the template. The deaminated bases can be introduced into DNA enzymatically, since both PolB1 and PolY1 are able to incorporate the aberrant DNA precursors dUTP and dITP Saccharolobus solfataricus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn the specific recognition of deaminated bases by polymerase PolB1 may represent an initial step in their repair while polymerase PolY1 may be involved in damage tolerance at the replication fork. The deaminated bases can be introduced into DNA enzymatically, since both PolB1 and PolY1 are able to incorporate the aberrant DNA precursors dUTP and dITP Saccharolobus solfataricus P2 diphosphate + DNAn+1
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 ?
deoxynucleoside triphosphate + DNAn specifically recognizes the presence of the deaminated bases hypoxanthine and uracil in the template by stalling DNA polymerization 3-4 bases upstream of these lesions and strongly associates with oligonucleotides containing them. PolB1 also stops at 8-oxoguanine and is unable to bypass an abasic site in the template. The deaminated bases can be introduced into DNA enzymatically, since both PolB1 and PolY1 are able to incorporate the aberrant DNA precursors dUTP and dITP Saccharolobus solfataricus P2 diphosphate + DNAn+1
-
 ?