Literature summary for 2.7.7.7 extracted from

Kaminski, A.M.; Bebenek, K.; Pedersen, L.C.; Kunkel, T.A.
DNA polymerase mu An inflexible scaffold for substrate flexibility (2020), DNA Repair, 93, 102932 .

Search for more literature for 2.7.7.7

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn	Homo sapiens	the template-dependent polymerase that can repair non-complementary DNA double strand breaks with unpaired 3' primer termini by nonhomologous end joining. Its role is to fill short gaps arising as intermediates in the process of V(D)J recombination and during processing of accidental double strand breaks	diphosphate + DNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NP87	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn	the template-dependent polymerase that can repair non-complementary DNA double strand breaks with unpaired 3' primer termini by nonhomologous end joining. Its role is to fill short gaps arising as intermediates in the process of V(D)J recombination and during processing of accidental double strand breaks	Homo sapiens	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase mu	-	Homo sapiens
Pol mu	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the template-dependent polymerase that can repair non-complementary DNA double strand breaks with unpaired 3' primer termini by nonhomologous end joining. Its role is to fill short gaps arising as intermediates in the process of V(D)J recombination and during processing of accidental double strand breaks	Homo sapiens

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Release 2023.1 (January 2023)