Literature summary for 2.7.7.7 extracted from

Antczak, N.M.; Walker, A.R.; Stern, H.R.; Leddin, E.M.; Palad, C.; Coulther, T.A.; Swett, R.J.; Cisneros, G.A.; Beuning, P.J.
Characterization of nine cancer-associated variants in human DNA polymerase kappa (2018), Chem. Res. Toxicol., 31, 697-711 .

Search for more literature for 2.7.7.7

Protein Variants

Protein Variants	Comment	Organism
E292K	more active than wild-type enzyme	Homo sapiens
F192C	more active than wild-type enzyme	Homo sapiens
I39T	more active than wild-type enzyme	Homo sapiens
L21F	more active than wild-type enzyme	Homo sapiens
P169T	more active than wild-type enzyme	Homo sapiens
R219I	less active than wild-type enzyme	Homo sapiens
R298H	less active than wild-type enzyme, markedly reduced thermal stability	Homo sapiens
Y432S	less active than wild-type enzyme, markedly reduced thermal stability	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UBT6	-	-

Synonyms

Synonyms	Comment	Organism
DNA polymerase kappa	-	Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
32	-	mutant enzyme R298H	Homo sapiens
36.4	-	mutant enzyme Y432S	Homo sapiens
40.4	-	mutant enzyme F192C	Homo sapiens
41.9	-	melting temperature, wild-type	Homo sapiens

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Release 2023.1 (January 2023)