Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2,3,4-tetrahydro-5-methoxynaphthalene-1,4-diol | i.e. nodulisporol. Strong inhibition of pol lambda, but does not influence the activities of mammalian pols alpha to kappa, and shows no effect on the activities of plant pols alpha and beta, prokaryotic pols, and other DNA metabolic enzymes such as calf terminal deoxynucleotidyl transferase, human immunodeficiency virus type-1 (HIV-1) reverse transcriptase, human telomerase, T7 RNA polymerase, and bovine deoxyribonuclease I | Homo sapiens | |
3,4-dihydro-4-hydroxy-8-methoxynaphthalen-1(2H)-one | i.e. nodulisporone. Strong inhibition of pol lambda, but does not influence the activities of mammalian pols alpha to kappa, and shows no effect on the activities of plant pols alpha and beta, prokaryotic pols, and other DNA metabolic enzymes such as calf terminal deoxynucleotidyl transferase, human immunodeficiency virus type-1 (HIV-1) reverse transcriptase, human telomerase, T7 RNA polymerase, and bovine deoxyribonuclease I | Homo sapiens | |
3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase lambda | - |
Homo sapiens |
Pol lambda | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.049 | - |
- |
Homo sapiens | 3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin |