Literature summary for 2.7.7.50 extracted from

Chen, P.; Zhou, Z.; Yao, X.; Pang, S.; Liu, M.; Jiang, W.; Jiang, J.; Zhang, Q.
Capping enzyme mRNA-cap/RNGTT regulates hedgehog pathway activity by antagonizing protein kinase A (2017), Sci. Rep., 7, 2891 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Drosophila melanogaster	5737	-

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Synonyms

Synonyms	Comment	Organism
mRNA-cap	the enzyme harbors RNA 5'-triphosphatase and mRNA 3'-guanylyltransferase domains	Drosophila melanogaster

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown impairs wing development and represses Hedgehog pathway signalling activity. Enzyme knockdown downregulates transcription factor Cubitus interruptus but upregulates smoothend protein levels	Drosophila melanogaster
metabolism	the enzyme regulates Hedgehog pathway signaling activity depending on its capping-enzyme activity in the cytoplasm and through antagonizing protein kinase A	Drosophila melanogaster

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Release 2023.1 (January 2023)