Literature summary for 2.7.7.50 extracted from

Tate, J.; Boldt, R.L.; McFadden, B.D.; DCosta, S.M.; Lewandowski, N.M.; Shatzer, A.N.; Gollnick, P.; Condit, R.C.
Biochemical analysis of the multifunctional vaccinia mRNA capping enzyme encoded by a temperature sensitive virus mutant (2016), Virology, 487, 27-40.

Search for more literature for 2.7.7.50

Organism

Organism	UniProt	Comment	Textmining
Vaccinia virus	P04298	mRNA-capping enzyme catalytic subunit	-
Vaccinia virus IHDW	P04298	mRNA-capping enzyme catalytic subunit	-

General Information

General Information	Comment	Organism
physiological function	in Dts36, a temperature sensitive virus mutant affecting the large subunit of the capping enzyme, of the three enzymatic activities required for mRNA capping, the guanylyltransferase and methyltransferase activities are compromised while the triphosphatase activity and the D12 subunit interaction are unaffected. The mutant enzyme is also defective in stimulating early gene transcription termination and intermediate gene transcription initiation in vitro	Vaccinia virus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)