Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | the enzyme directs incoming nucleotides to its active site through Mg2+-dependent dynamics within its F motif. Mg2+-bound nucleotide first binds next to the tunnel entry of the RNA-dependent RNA polymerase(RdRp)-specific entry tunnel. Interactions with the triphosphate moiety orient the nucleotide such that its base moiety enters first. Dynamics of RdRp motifs F1 + F3 then allow the nucleotide to interrogate the RNA template base prior to nucleotide insertion into the active site. These dynamics are finely regulated by a second magnesium dication, thus coordinating the entry of a magnesium-bound nucleotide with shuttling of the second magnesium necessary for the two-metal ion catalysis | Hepacivirus C |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Hepacivirus C | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Hepacivirus C | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNA-dependent RNA polymerase | - |
Hepacivirus C |
General Information | Comment | Organism |
---|---|---|
drug target | since virally-encoded RNA-dependent RNA polymerases of RNA viruses synthesizes new genomes in the infected host they are prime targets for antiviral therapy | Hepacivirus C |
physiological function | virally-encoded RNA-dependent RNA polymerases of RNA viruses synthesizes new genomes in the infected host | Hepacivirus C |