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Literature summary for 2.7.7.48 extracted from

  • Konkolova, E.; Dejmek, M.; Hrebabecky, H.; Sala, M.; Boeserle, J.; Nencka, R.; Boura, E.
    Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses (2020), Antiviral Res., 182, 104899 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Yellow fever virus
expression in Escherichia coli West Nile virus
expression in Escherichia coli Japanese encephalitis virus
expression in Escherichia coli Zika virus
expression in Escherichia coli Dengue virus type 3
expression in Escherichia coli Tick-borne encephalitis virus

Inhibitors

Inhibitors Comment Organism Structure
remdesivir triphosphate remdesivir or its derivatives have the potential to become broad-spectrum antiviral agent effective against many RNA viruses Dengue virus type 3
remdesivir triphosphate remdesivir or its derivatives have the potential to become broad-spectrum antiviral agent effective against many RNA viruses Japanese encephalitis virus
remdesivir triphosphate remdesivir or its derivatives have the potential to become broad-spectrum antiviral agent effective against many RNA viruses Tick-borne encephalitis virus
remdesivir triphosphate remdesivir or its derivatives have the potential to become broad-spectrum antiviral agent effective against many RNA viruses West Nile virus
remdesivir triphosphate remdesivir or its derivatives have the potential to become broad-spectrum antiviral agent effective against many RNA viruses Yellow fever virus
remdesivir triphosphate remdesivir or its derivatives have the potential to become broad-spectrum antiviral agent effective against many RNA viruses Zika virus

Organism

Organism UniProt Comment Textmining
Dengue virus type 3
-
-
-
Japanese encephalitis virus
-
-
-
Tick-borne encephalitis virus Q01299
-
-
West Nile virus
-
-
-
Yellow fever virus
-
-
-
Zika virus Q32ZE1 genome polyprotein
-

Purification (Commentary)

Purification (Comment) Organism
-
 Yellow fever virus
-
 West Nile virus
-
 Japanese encephalitis virus
-
 Zika virus
-
 Dengue virus type 3
-
 Tick-borne encephalitis virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNAn
-
 Yellow fever virus diphosphate + RNAn+1
-
 ?
ATP + RNAn
-
 West Nile virus diphosphate + RNAn+1
-
 ?
ATP + RNAn
-
 Japanese encephalitis virus diphosphate + RNAn+1
-
 ?
ATP + RNAn
-
 Zika virus diphosphate + RNAn+1
-
 ?
ATP + RNAn
-
 Dengue virus type 3 diphosphate + RNAn+1
-
 ?
ATP + RNAn
-
 Tick-borne encephalitis virus diphosphate + RNAn+1
-
 ?
CTP + RNAn
-
 Yellow fever virus diphosphate + RNAn+1
-
 ?
CTP + RNAn
-
 West Nile virus diphosphate + RNAn+1
-
 ?
CTP + RNAn
-
 Japanese encephalitis virus diphosphate + RNAn+1
-
 ?
CTP + RNAn
-
 Zika virus diphosphate + RNAn+1
-
 ?
CTP + RNAn
-
 Dengue virus type 3 diphosphate + RNAn+1
-
 ?
CTP + RNAn
-
 Tick-borne encephalitis virus diphosphate + RNAn+1
-
 ?
GTP + RNAn
-
 Yellow fever virus diphosphate + RNAn+1
-
 ?
GTP + RNAn
-
 West Nile virus diphosphate + RNAn+1
-
 ?
GTP + RNAn
-
 Japanese encephalitis virus diphosphate + RNAn+1
-
 ?
GTP + RNAn
-
 Zika virus diphosphate + RNAn+1
-
 ?
GTP + RNAn
-
 Dengue virus type 3 diphosphate + RNAn+1
-
 ?
GTP + RNAn
-
 Tick-borne encephalitis virus diphosphate + RNAn+1
-
 ?
UTP + RNAn
-
 Yellow fever virus diphosphate + RNAn+1
-
 ?
UTP + RNAn
-
 West Nile virus diphosphate + RNAn+1
-
 ?
UTP + RNAn
-
 Japanese encephalitis virus diphosphate + RNAn+1
-
 ?
UTP + RNAn
-
 Zika virus diphosphate + RNAn+1
-
 ?
UTP + RNAn
-
 Dengue virus type 3 diphosphate + RNAn+1
-
 ?
UTP + RNAn
-
 Tick-borne encephalitis virus diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
NS5
-
 Yellow fever virus
NS5
-
 West Nile virus
NS5
-
 Japanese encephalitis virus
NS5
-
 Zika virus
NS5
-
 Dengue virus type 3
NS5
-
 Tick-borne encephalitis virus
RDRP
-
 Yellow fever virus
RDRP
-
 West Nile virus
RDRP
-
 Japanese encephalitis virus
RDRP
-
 Zika virus
RDRP
-
 Dengue virus type 3
RDRP
-
 Tick-borne encephalitis virus
RNA-dependent RNA polymerase
-
 Yellow fever virus
RNA-dependent RNA polymerase
-
 West Nile virus
RNA-dependent RNA polymerase
-
 Japanese encephalitis virus
RNA-dependent RNA polymerase
-
 Zika virus
RNA-dependent RNA polymerase
-
 Dengue virus type 3
RNA-dependent RNA polymerase
-
 Tick-borne encephalitis virus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00026
-
 pH and temperature not specified in the publication Yellow fever virus remdesivir triphosphate
0.00101
-
 pH and temperature not specified in the publication Tick-borne encephalitis virus remdesivir triphosphate
0.00136
-
 pH and temperature not specified in the publication Zika virus remdesivir triphosphate
0.0014
-
 pH and temperature not specified in the publication Dengue virus type 3 remdesivir triphosphate
0.00166
-
 pH and temperature not specified in the publication West Nile virus remdesivir triphosphate
0.00214
-
 pH and temperature not specified in the publication Japanese encephalitis virus remdesivir triphosphate