Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(4-bromophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine | reversible and non-competitive with nucleotides. Inhibitor appear to form a reversible covalent bond with the NS5B cysteine 366 | Hepacivirus C | |
5-(4-chlorophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine | reversible and non-competitive with nucleotides. Inhibitor appear to form a reversible covalent bond with the NS5B cysteine 366 | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Hepacivirus C |
Synonyms | Comment | Organism |
---|---|---|
HCN NS5B protein | - |
Hepacivirus C |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00044 | - |
37°C, pH 7.5 | Hepacivirus C | 5-(4-bromophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine | |
0.00054 | - |
37°C, pH 7.5 | Hepacivirus C | 5-(4-chlorophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine |