Application | Comment | Organism |
---|---|---|
medicine | streptomycin continues to be an important drug for synergistic therapy of serious enterococcal infections | Enterococcus faecalis |
Cloned (Comment) | Organism |
---|---|
aadA resistence gene transferred vi filter mating from Enterococcus faecalis W4770 to Enterococcus faecalis JH2-2, PCR amplified aadA gene cloned into vector pCRII and transformed into Escherichia coli DH5-alpha | Enterococcus faecalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + streptomycin | Enterococcus faecalis | - |
diphosphate + 3''-adenylylstreptomycin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecalis | Q71UU1 | W4770, aadA nucleotide sequence | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + spectinomycin | - |
Enterococcus faecalis | diphosphate + 9-adenylylspectinomycin | - |
? | |
ATP + streptomycin | - |
Enterococcus faecalis | diphosphate + 3''-adenylylstreptomycin | - |
? | |
ATP + tetracyclin | - |
Enterococcus faecalis | diphosphate + 3''adenylyltetracyclin | - |
? | |
additional information | no resistance to ampicillin, chloramphenicol, ciprofloxacin, gentamicin, imipenem, penicillin, quinupristin/dalfopristin, rifampin, teicoplanin, and vancomycin mediated | Enterococcus faecalis | ? | - |
? |