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Literature summary for 2.7.7.3 extracted from

  • Skepper, C.K.; Moreau, R.J.; Appleton, B.A.; Benton, B.M.; Drumm, J.E.; Feng, B.Y.; Geng, M.; Hu, C.; Li, C.; Lingel, A.; Lu, Y.; Mamo, M.; Mergo, W.; Mostafavi, M.; Rath, C.M.; Steffek, M.; Takeoka, K.T.; Uehara, K.; Wang, L.; Wei, J.R.; Xie, L.; Xu, W.; Zhang, Q.; de Vicente, J.
    Discovery and optimization of phosphopantetheine adenylyltransferase inhibitors with Gram-negative antibacterial activity (2018), J. Med. Chem., 61, 3325-3349 .
    View publication on PubMed
Search for more literature for 2.7.7.3

Inhibitors

Inhibitors Comment Organism Structure
(3R)-3-(3-chlorophenyl)-3-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
-
 Escherichia coli
(3R)-3-(3-chlorophenyl)-3-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
-
 Pseudomonas aeruginosa
(3R)-3-(3-chlorophenyl)-3-[(7-[[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
-
 Escherichia coli
(3R)-3-(3-chlorophenyl)-3-[(7-[[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
-
 Pseudomonas aeruginosa
(3R)-3-([7-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl]amino)-3-(3-chlorophenyl)propanenitrile
-
 Escherichia coli
(3R)-3-([7-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl]amino)-3-(3-chlorophenyl)propanenitrile
-
 Pseudomonas aeruginosa
1-[5-[(2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-7-yl)amino]-2,3-dihydro-1H-indol-1-yl]ethan-1-one
-
 Escherichia coli
1-[5-[(2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-7-yl)amino]-2,3-dihydro-1H-indol-1-yl]ethan-1-one
-
 Pseudomonas aeruginosa
3-[4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-1-(methoxycarbonyl)piperidin-4-yl]propanoic acid
-
 Escherichia coli
3-[4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-1-(methoxycarbonyl)piperidin-4-yl]propanoic acid
-
 Pseudomonas aeruginosa
methyl (R)-4-(3-(2-cyano-1-((5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino)ethyl)benzyl)piperidine-1-carboxylate
-
 Escherichia coli
methyl (R)-4-(3-(2-cyano-1-((5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino)ethyl)benzyl)piperidine-1-carboxylate
-
 Pseudomonas aeruginosa
methyl 4-(2-cyanoethyl)-4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]piperidine-1-carboxylate
-
 Escherichia coli
methyl 4-(2-cyanoethyl)-4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]piperidine-1-carboxylate
-
 Pseudomonas aeruginosa
methyl 4-(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]benzene-1-sulfonyl)piperidine-1-carboxylate
-
 Escherichia coli
methyl 4-(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]benzene-1-sulfonyl)piperidine-1-carboxylate
-
 Pseudomonas aeruginosa
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-(3-hydroxypropyl)piperidine-1-carboxylate
-
 Escherichia coli
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-(3-hydroxypropyl)piperidine-1-carboxylate
-
 Pseudomonas aeruginosa
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[(Z)-(methoxyimino)methyl]piperidine-1-carboxylate
-
 Escherichia coli
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[(Z)-(methoxyimino)methyl]piperidine-1-carboxylate
-
 Pseudomonas aeruginosa
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[[(2-hydroxyethyl)amino]methyl]piperidine-1-carboxylate
-
 Escherichia coli
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[[(2-hydroxyethyl)amino]methyl]piperidine-1-carboxylate
-
 Pseudomonas aeruginosa
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)sulfanyl]piperidine-1-carboxylate
-
 Escherichia coli
methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)sulfanyl]piperidine-1-carboxylate
-
 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6I6
-
-
Pseudomonas aeruginosa Q9I6D1
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000011
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa (3R)-3-(3-chlorophenyl)-3-[(7-[[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
0.0000012
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa 1-[5-[(2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-7-yl)amino]-2,3-dihydro-1H-indol-1-yl]ethan-1-one
0.0000024
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa methyl 4-(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]benzene-1-sulfonyl)piperidine-1-carboxylate
0.0000025
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa methyl (R)-4-(3-(2-cyano-1-((5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino)ethyl)benzyl)piperidine-1-carboxylate
0.0000027
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)sulfanyl]piperidine-1-carboxylate
0.0000032
-
 pH 7.5, temperature not specified in the publication Escherichia coli 3-[4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-1-(methoxycarbonyl)piperidin-4-yl]propanoic acid
0.000004
-
 pH 7.5, temperature not specified in the publication Escherichia coli (3R)-3-([7-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl]amino)-3-(3-chlorophenyl)propanenitrile
0.0000043
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa (3R)-3-([7-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl]amino)-3-(3-chlorophenyl)propanenitrile
0.0000049
-
 pH 7.5, temperature not specified in the publication Escherichia coli methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[(Z)-(methoxyimino)methyl]piperidine-1-carboxylate
0.0000051
-
 pH 7.5, temperature not specified in the publication Escherichia coli methyl 4-(2-cyanoethyl)-4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]piperidine-1-carboxylate
0.0000054
-
 pH 7.5, temperature not specified in the publication Escherichia coli (3R)-3-(3-chlorophenyl)-3-[(7-[[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
0.0000075
-
 pH 7.5, temperature not specified in the publication Escherichia coli methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[[(2-hydroxyethyl)amino]methyl]piperidine-1-carboxylate
0.0000078
-
 pH 7.5, temperature not specified in the publication Escherichia coli 1-[5-[(2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-5-methyl-1H-imidazo[4,5-b]pyridin-7-yl)amino]-2,3-dihydro-1H-indol-1-yl]ethan-1-one
0.0000081
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[(Z)-(methoxyimino)methyl]piperidine-1-carboxylate
0.0000082
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa 3-[4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-1-(methoxycarbonyl)piperidin-4-yl]propanoic acid
0.0000082
-
 pH 7.5, temperature not specified in the publication Escherichia coli methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)sulfanyl]piperidine-1-carboxylate
0.0000088
-
 pH 7.5, temperature not specified in the publication Escherichia coli methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-(3-hydroxypropyl)piperidine-1-carboxylate
0.0000093
-
 pH 7.5, temperature not specified in the publication Escherichia coli methyl (R)-4-(3-(2-cyano-1-((5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino)ethyl)benzyl)piperidine-1-carboxylate
0.0000093
-
 pH 7.5, temperature not specified in the publication Escherichia coli methyl 4-(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]benzene-1-sulfonyl)piperidine-1-carboxylate
0.00001
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-(3-hydroxypropyl)piperidine-1-carboxylate
0.000013
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa methyl 4-(2-cyanoethyl)-4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]piperidine-1-carboxylate
0.000024
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa methyl 4-[(3-[(1R)-2-cyano-1-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethyl]phenyl)methyl]-4-[[(2-hydroxyethyl)amino]methyl]piperidine-1-carboxylate
0.000056
-
 pH 7.5, temperature not specified in the publication Escherichia coli (3R)-3-(3-chlorophenyl)-3-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile
0.000064
-
 pH 7.5, temperature not specified in the publication Pseudomonas aeruginosa (3R)-3-(3-chlorophenyl)-3-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]propanenitrile