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Literature summary for 2.7.7.23 extracted from

  • Debets, M.F.; Tastan, O.Y.; Wisnovsky, S.P.; Malaker, S.A.; Angelis, N.; Moeckl, L.K.R.; Choi, J.; Flynn, H.; Wagner, L.J.S.; Bineva-Todd, G.; Antonopoulos, A.; Cioce, A.; Browne, W.M.; Li, Z.; Briggs, D.C.; Douglas, H.L.; Hess, G.T.; Agbay, A.J.; Roustan, C.; Kjaer, S.; Haslam, S.M.; Snijders, A.P.; Bassik, M.C.; , M.
    Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation (2020), Proc. Natl. Acad. Sci. USA, 117, 25293-25301 .
    View publication on PubMed
Search for more literature for 2.7.7.23

Protein Variants

Protein Variants Comment Organism
F383A the mutant can use GalNAzMe-1-phosphate as substrate Homo sapiens
F383G the mutant cannot use GalNAzMe-1-phosphate as substrate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UTP + N-acetyl-alpha-D-galactosamine 1-phosphate Homo sapiens reaction of EC 2.7.7.83 diphosphate + UDP-N-acetyl-alpha-D-galactosamine
-
 ?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Homo sapiens
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16222
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UTP + GalNAzMe-1-phosphate the reaction is catalyzed only by mutant F383A Homo sapiens diphosphate + UDP-GalNAzMe
-
 ?
UTP + N-acetyl-alpha-D-galactosamine 1-phosphate reaction of EC 2.7.7.83 Homo sapiens diphosphate + UDP-N-acetyl-alpha-D-galactosamine
-
 ?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Homo sapiens diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
AGX1
-
 Homo sapiens