BRENDA - Enzyme Database show
show all sequences of 2.7.6.1

Mammalian phosphoribosyl-pyrophosphate synthetase

Tatibana, M.; Kita, K.; Taira, M.; Ishijima, S.; Sonoda, T.; Ishizuka, T.; Iizasa, T.; Ahmad, I.; Adv. Enzyme Regul. 35, 229-249 (1995)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
phosphate
specific and absolute requirement
Homo sapiens
phosphate
specific and absolute requirement
Rattus norvegicus
sulfate
can partially replace phosphate in activation
Homo sapiens
sulfate
can partially replace phosphate in activation
Rattus norvegicus
Cloned(Commentary)
Commentary
Organism
expression of isoenzymes PRSI and PRSII in Escherichia coli
Rattus norvegicus
expression of isoenzymes PRSI and PRSII in Escherichia coli
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
ADP
-
Homo sapiens
ADP
one of the most effective
Rattus norvegicus
AMP
-
Homo sapiens
AMP
one of the most effective
Rattus norvegicus
CTP
-
Homo sapiens
CTP
weak inhibition at 1 mM
Rattus norvegicus
GDP
-
Homo sapiens
GDP
one of the most effective
Rattus norvegicus
GTP
-
Homo sapiens
GTP
weak inhibition at 1 mM
Rattus norvegicus
PRPP synthetase-associated proteins
inhibit catalytic and perhaps regulatory functions of the enzyme
Homo sapiens
PRPP synthetase-associated proteins
inhibit catalytic and perhaps regulatory functions of the enzyme
Rattus norvegicus
UDP
10%-16% inhibition at 1 mM
Homo sapiens
UDP
10%-16% inhibition at 1 mM
Rattus norvegicus
UMP
10%-18% inhibition at 1 mM
Homo sapiens
UMP
10%-18% inhibition at 1 mM
Rattus norvegicus
UTP
weak inhibition at 1 mM
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
D-ribose 5-phosphate
pH 7.4, 37ºC, isoenzyme rPRSI
Rattus norvegicus
0.044
-
ATP
pH 7.4, 37ºC, isoenzyme rPRSI
Rattus norvegicus
0.06
-
ATP
pH 7.4, 37ºC, isoenzyme rPRSII
Rattus norvegicus
0.073
-
D-ribose 5-phosphate
pH 7.4, 37ºC, isoenzyme rPRSII
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
brush border
intestinal mucosa
Rattus norvegicus
5903
-
cytosol
60% of the total activity, fractionation by discontinuous sucrose density gradient centrifugation
Rattus norvegicus
5829
-
microsome
30% of the total activity, fractionation by discontinuous sucrose density gradient centrifugation
Rattus norvegicus
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
-
Homo sapiens
additional information
-
the catalytic subunit complexes with the PRPP synthetase-associated protein of 39000 Da, PAP39, to form highly aggregated forms
Rattus norvegicus
34000
-
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII
Rattus norvegicus
39000
-
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII
Rattus norvegicus
41000
-
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII
Rattus norvegicus
68000
-
x * 68000, gel filtration in the presence of MgCl2 1 M
Rattus norvegicus
1000000
-
-
Homo sapiens
1000000
-
chromatography on DEAE-Toyopearl
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-ribose 5-phosphate
Homo sapiens
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens
r
ATP + D-ribose 5-phosphate
Rattus norvegicus
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Rattus norvegicus
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
rat
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipose tissue
isoenzymes PRSI and PRSII
Rattus norvegicus
-
adrenal gland
isoenzyme PRSI
Rattus norvegicus
-
brain
isoenzyme PRSI
Rattus norvegicus
-
erythrocyte
-
Homo sapiens
-
glioblastoma cell
cell line
Homo sapiens
-
liver
-
Rattus norvegicus
-
lung
isoenzyme PRSII
Rattus norvegicus
-
spleen
isoenzyme PRSII
Rattus norvegicus
-
testis
isoenzymes PRSI and PRSII
Rattus norvegicus
-
thymus
isoenzymes PRSI and PRSII
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Homo sapiens
additional information
-
33400 U/mg and 46200 U/mg for PRSI and PRSII purified isoenzymes, respectively; purified enzyme has an activity of 7280 U/mg
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-ribose 5-phosphate
-
642731
Homo sapiens
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Homo sapiens
r
ATP + D-ribose 5-phosphate
-
642731
Rattus norvegicus
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Rattus norvegicus
r
ATP + D-ribose 5-phosphate
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
642731
Homo sapiens
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Homo sapiens
r
ATP + D-ribose 5-phosphate
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
642731
Rattus norvegicus
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Rattus norvegicus
r
Subunits
Subunits
Commentary
Organism
?
-
Homo sapiens
?
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII; x * 68000, gel filtration in the presence of MgCl2 1 M
Rattus norvegicus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
49
-
-
Homo sapiens
49
-
half-life of 250 min, 90 min and 0.5 min for native enzyme, isoenzymes rPRSI and rPRSII, respectively
Rattus norvegicus
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Rattus norvegicus
isoenzyme rPRSII
4.4
4.3
Rattus norvegicus
isoenzyme rPRSI
-
4.4
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
phosphate
specific and absolute requirement
Homo sapiens
phosphate
specific and absolute requirement
Rattus norvegicus
sulfate
can partially replace phosphate in activation
Homo sapiens
sulfate
can partially replace phosphate in activation
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of isoenzymes PRSI and PRSII in Escherichia coli
Rattus norvegicus
expression of isoenzymes PRSI and PRSII in Escherichia coli
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ADP
-
Homo sapiens
ADP
one of the most effective
Rattus norvegicus
AMP
-
Homo sapiens
AMP
one of the most effective
Rattus norvegicus
CTP
-
Homo sapiens
CTP
weak inhibition at 1 mM
Rattus norvegicus
GDP
-
Homo sapiens
GDP
one of the most effective
Rattus norvegicus
GTP
-
Homo sapiens
GTP
weak inhibition at 1 mM
Rattus norvegicus
PRPP synthetase-associated proteins
inhibit catalytic and perhaps regulatory functions of the enzyme
Homo sapiens
PRPP synthetase-associated proteins
inhibit catalytic and perhaps regulatory functions of the enzyme
Rattus norvegicus
UDP
10%-16% inhibition at 1 mM
Homo sapiens
UDP
10%-16% inhibition at 1 mM
Rattus norvegicus
UMP
10%-18% inhibition at 1 mM
Homo sapiens
UMP
10%-18% inhibition at 1 mM
Rattus norvegicus
UTP
weak inhibition at 1 mM
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
D-ribose 5-phosphate
pH 7.4, 37ºC, isoenzyme rPRSI
Rattus norvegicus
0.044
-
ATP
pH 7.4, 37ºC, isoenzyme rPRSI
Rattus norvegicus
0.06
-
ATP
pH 7.4, 37ºC, isoenzyme rPRSII
Rattus norvegicus
0.073
-
D-ribose 5-phosphate
pH 7.4, 37ºC, isoenzyme rPRSII
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
brush border
intestinal mucosa
Rattus norvegicus
5903
-
cytosol
60% of the total activity, fractionation by discontinuous sucrose density gradient centrifugation
Rattus norvegicus
5829
-
microsome
30% of the total activity, fractionation by discontinuous sucrose density gradient centrifugation
Rattus norvegicus
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
-
Homo sapiens
additional information
-
the catalytic subunit complexes with the PRPP synthetase-associated protein of 39000 Da, PAP39, to form highly aggregated forms
Rattus norvegicus
34000
-
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII
Rattus norvegicus
39000
-
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII
Rattus norvegicus
41000
-
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII
Rattus norvegicus
68000
-
x * 68000, gel filtration in the presence of MgCl2 1 M
Rattus norvegicus
1000000
-
-
Homo sapiens
1000000
-
chromatography on DEAE-Toyopearl
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-ribose 5-phosphate
Homo sapiens
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens
r
ATP + D-ribose 5-phosphate
Rattus norvegicus
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Rattus norvegicus
r
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipose tissue
isoenzymes PRSI and PRSII
Rattus norvegicus
-
adrenal gland
isoenzyme PRSI
Rattus norvegicus
-
brain
isoenzyme PRSI
Rattus norvegicus
-
erythrocyte
-
Homo sapiens
-
glioblastoma cell
cell line
Homo sapiens
-
liver
-
Rattus norvegicus
-
lung
isoenzyme PRSII
Rattus norvegicus
-
spleen
isoenzyme PRSII
Rattus norvegicus
-
testis
isoenzymes PRSI and PRSII
Rattus norvegicus
-
thymus
isoenzymes PRSI and PRSII
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Homo sapiens
additional information
-
33400 U/mg and 46200 U/mg for PRSI and PRSII purified isoenzymes, respectively; purified enzyme has an activity of 7280 U/mg
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-ribose 5-phosphate
-
642731
Homo sapiens
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Homo sapiens
r
ATP + D-ribose 5-phosphate
-
642731
Rattus norvegicus
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Rattus norvegicus
r
ATP + D-ribose 5-phosphate
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
642731
Homo sapiens
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Homo sapiens
r
ATP + D-ribose 5-phosphate
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
642731
Rattus norvegicus
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
642731
Rattus norvegicus
r
Subunits (protein specific)
Subunits
Commentary
Organism
?
-
Homo sapiens
?
x * 34000 + x * 39000 + x * 41000, SDS-PAGE, the 34000 Da subunit is the catalytic subunit which appears as PRSI or PRSII; x * 68000, gel filtration in the presence of MgCl2 1 M
Rattus norvegicus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
49
-
-
Homo sapiens
49
-
half-life of 250 min, 90 min and 0.5 min for native enzyme, isoenzymes rPRSI and rPRSII, respectively
Rattus norvegicus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Rattus norvegicus
isoenzyme rPRSII
4.4
4.3
Rattus norvegicus
isoenzyme rPRSI
-
4.4
Other publictions for EC 2.7.6.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738194
Bibi
Pcal_1127, a highly stable and ...
Pyrobaculum calidifontis, Pyrobaculum calidifontis JCM 11548
Extremophiles
20
821-830
2016
-
-
1
-
-
1
3
2
-
9
1
2
-
4
-
-
1
-
-
1
1
-
10
1
1
-
1
1
1
-
-
5
-
1
-
-
-
1
5
-
-
1
-
3
-
2
-
9
1
2
-
-
-
1
-
1
1
-
10
1
1
-
1
1
1
-
-
1
-
1
1
-
1
1
729695
Andersen
Structure of dimeric, recombin ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Extremophiles
19
407-415
2015
-
-
1
1
-
-
-
-
-
-
1
2
-
5
-
-
1
-
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
738085
Timofeev
Crystallization and preliminar ...
Escherichia coli
Crystallogr. Rep.
60
685-688
2015
-
-
-
1
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
723338
Hong
Ribose-phosphate pyrophosphoki ...
Culex pipiens
Parasitol. Res.
112
847-854
2013
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721253
Moran
Phosphoribosylpyrophosphate sy ...
Homo sapiens
Am. J. Med. Genet. A
158A
455-460
2012
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721377
Zakataeva
Wild-type and feedback-resista ...
Bacillus amyloliquefaciens, Bacillus amyloliquefaciens IAM 1523
Appl. Microbiol. Biotechnol.
93
2023-2033
2012
1
-
1
-
3
-
2
8
-
-
1
-
-
9
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
7
1
-
1
-
-
3
-
7
2
-
8
-
-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723220
Zhong
Phosphoribosyl pyrophosphate s ...
Aspergillus nidulans, Aspergillus nidulans WJA01
Mol. Microbiol.
86
894-907
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
723571
Breda
Wild-type phosphoribosylpyroph ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis Rv1017c
PLoS ONE
7
e39245
2012
-
-
1
-
-
-
4
2
-
1
-
-
-
4
-
-
1
-
-
-
2
1
8
1
-
-
-
2
-
-
-
-
1
-
3
-
-
1
-
-
-
-
3
4
1
2
-
1
-
-
-
-
-
1
-
-
2
1
8
1
-
-
-
2
-
-
-
-
-
-
-
-
2
2
722354
Alderwick
Biochemical characterization o ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Glycobiology
21
410-425
2011
1
-
1
-
-
-
1
1
1
3
-
-
-
153
-
-
1
-
-
-
-
-
4
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1
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Mycobacterium tuberculosis pho ...
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1
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7
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2
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1
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4
1
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1
8
1
1
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1
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3
3
696960
Jimenez
Phosphoribosyl pyrophosphate s ...
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Higher biomass accumulation by ...
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1
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Arts syndrome is caused by los ...
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1
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Mutations in PRPS1, which enco ...
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Crystal structure of human pho ...
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3
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1
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2
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3
1
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1
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4
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1
1
3
2
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10
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3
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4
3
1
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Napolitano
Preliminary crystallographic a ...
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Kaida
Identification of a novel p300 ...
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661701
Hove-Jensen
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1
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1
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Phosphoribosylpyrophosphate sy ...
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3
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Krath
Class II recombinant phosphori ...
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642734
Eriksen
Structural basis for the funct ...
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1
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Willemoes
Steady state kinetic model for ...
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7
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3
7
3
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1
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1
1
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1
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489771
Kian
Purine biosynthesis de novo in ...
Bos taurus
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2
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1
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642736
Krath
Organellar and cytosolic local ...
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1
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1
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16
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1
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1
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1
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1
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1
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3
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1
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16
-
1
-
1
-
-
-
-
-
-
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-
-
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642725
Okada
-
Variation of phosphoribosylpyr ...
Homo sapiens
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2
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1
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1
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1
1
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2
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1
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642726
Sonoda
Kinetic and regulatory propert ...
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12
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2
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1
2
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1
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1
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3
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7
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12
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1
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1
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2
9
1
2
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1
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1
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3
-
2
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642728
Ishijima
Partial reconstitution of mamm ...
Rattus norvegicus
Biochim. Biophys. Acta
1342
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1997
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1
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2
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1
1
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1
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2
-
2
-
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-
-
-
-
-
-
-
-
-
-
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642732
Willemoes
Binding of divalent magnesium ...
Escherichia coli
Biochemistry
36
5078-5083
1997
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1
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-
1
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1
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1
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1
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-
-
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-
-
-
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642735
Gallois
Purification and characterizat ...
Hevea brasiliensis
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4
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-
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19
3
1
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4
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2
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4
1
1
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1
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-
-
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642723
Parry
Carbocyclic analogues of D-rib ...
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6
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6
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10
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2
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2
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642733
Becker
Overexpression of the normal p ...
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2
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1
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2
2
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1
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642741
Bentsen
Overexpression of Bacillus sub ...
Bacillus subtilis
Proteins
24
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1996
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1
1
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3
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1
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1
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-
-
-
-
-
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-
-
-
-
-
-
-
-
642724
Balzarini
-
Kinetic properties of adenine ...
Escherichia coli, Homo sapiens, Rattus norvegicus
Nucleosides Nucleotides
14
1861-1871
1995
-
-
-
-
-
-
6
27
-
-
-
3
-
3
-
-
-
-
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2
-
-
29
-
3
-
-
-
-
-
-
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5
-
4
-
-
-
-
-
-
-
4
6
5
27
-
-
-
3
-
-
-
-
-
2
-
-
29
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
642731
Tatibana
Mammalian phosphoribosyl-pyrop ...
Homo sapiens, Rattus norvegicus
Adv. Enzyme Regul.
35
229-249
1995
4
-
2
-
-
-
17
4
3
-
8
2
-
5
-
-
-
-
-
11
2
-
4
2
-
-
2
-
-
-
-
-
-
2
-
4
-
2
-
-
-
-
-
17
-
4
3
-
8
2
-
-
-
-
-
11
2
-
4
2
-
-
2
-
-
-
-
2
-
-
-
-
-
-
642739
Jarori
Conformation of MgATP bound to ...
Salmonella enterica subsp. enterica serovar Typhimurium
Eur. J. Biochem.
230
517-524
1995
-
-
-
1
-
-
-
-
-
-
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1
-
1
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1
1
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1
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1
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-
1
1
-
-
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-
-
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-
-
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642719
Nosal
Overexpression, purification, ...
Homo sapiens
J. Biol. Chem.
268
10168-10175
1993
2
-
1
-
-
1
8
7
-
1
2
1
-
3
-
-
1
-
-
-
2
-
2
-
1
-
1
-
3
1
2
-
-
2
-
2
-
1
-
-
-
1
-
8
-
7
-
1
2
1
-
-
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1
-
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2
-
2
-
1
-
1
-
3
1
2
2
-
-
-
-
-
-
642715
Ishijima
Expression of rat phosphoribos ...
Rattus norvegicus
J. Biol. Chem.
266
15693-15697
1991
3
-
1
-
-
-
8
4
-
-
3
1
-
3
-
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1
-
-
2
2
1
2
1
-
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1
-
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2
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3
-
1
-
-
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8
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4
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3
1
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1
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2
2
1
2
1
-
-
1
-
-
-
-
2
-
-
-
-
-
-
642713
Arnvig
Purification and properties of ...
Bacillus subtilis
Eur. J. Biochem.
192
195-200
1990
1
-
1
-
-
1
7
2
-
3
2
1
-
4
-
-
1
1
-
-
1
1
2
1
-
-
-
-
1
1
-
-
-
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1
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1
-
-
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1
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7
-
2
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3
2
1
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1
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1
1
2
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
642721
Kita
Rat liver phosphoribosyl pyrop ...
Rattus norvegicus
J. Biochem.
105
736-741
1989
-
-
-
-
-
-
-
-
-
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5
1
-
2
-
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1
-
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2
1
1
2
1
-
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-
-
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5
1
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1
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2
1
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642711
Switzer
Phosphoribosylpyrophosphate sy ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium Su 422
Methods Enzymol.
51
3-11
1978
1
-
-
-
-
1
11
4
-
2
3
-
-
44
-
-
1
-
-
-
1
1
16
2
1
-
-
-
1
-
-
-
2
-
1
1
-
-
-
-
-
1
1
11
2
4
-
2
3
-
-
-
-
1
-
-
1
1
16
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
642712
Roth
Ribosephosphate pyrophosphokin ...
Rattus norvegicus
Methods Enzymol.
51
12-17
1978
3
-
-
-
-
1
5
2
-
1
2
1
-
1
-
-
1
-
-
1
1
1
3
1
-
-
-
-
1
-
-
-
1
-
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3
-
-
-
-
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1
-
5
1
2
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1
2
1
-
-
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1
-
1
1
1
3
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
642709
Ashihara
-
Characterization of phosphorib ...
Spinacia oleracea
Z. Pflanzenphysiol.
83
379-392
1977
-
-
-
-
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1
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1
3
-
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1
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1
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1
1
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1
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-
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1
-
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1
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-
-
-
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1
1
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1
3
-
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1
-
1
1
-
1
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
642714
Schubert
Studies of the quaternary stru ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium Su 422
J. Biol. Chem.
250
7492-7500
1975
-
-
-
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-
-
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6
2
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4
-
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1
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4
1
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-
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6
2
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1
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642720
Becker
Human phosphoribosylpyrophosph ...
Homo sapiens
J. Biol. Chem.
250
6822-6830
1975
-
-
-
-
-
-
5
3
-
-
2
-
-
2
-
-
1
-
-
2
2
-
1
1
1
-
1
-
-
-
-
-
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2
-
-
-
-
-
-
-
-
-
5
-
3
-
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2
-
-
-
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1
-
2
2
-
1
1
1
-
1
-
-
-
-
2
-
-
-
-
-
-
642710
Switzer
-
Phosphoribosylpyrophosphate sy ...
Columba sp., Escherichia coli, Gallus gallus, Homo sapiens, Mus musculus, Ophiodon elongatus, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
10
607-629
1974
5
-
-
-
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2
25
7
2
12
11
5
-
8
-
-
2
8
-
7
-
-
44
3
-
-
-
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2
-
-
-
-
-
-
5
-
-
-
-
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2
-
25
-
7
2
12
11
5
-
-
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2
-
7
-
-
44
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
642716
Roth
Purification and properties of ...
Rattus norvegicus
J. Biol. Chem.
249
291-296
1974
1
-
-
-
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1
1
3
-
4
2
1
-
2
-
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1
-
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2
-
1
6
1
1
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-
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1
-
1
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-
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1
-
-
-
-
-
1
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1
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3
-
4
2
1
-
-
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1
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2
-
1
6
1
1
-
-
-
1
-
1
-
-
-
-
-
-
-
642718
Switzer
Regulation and mechanism of ph ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
248
1063-1073
1973
-
-
-
-
-
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16
-
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1
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1
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2
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-
-
-
-
-
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-
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-
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-
16
-
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1
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-
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-
-
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642722
Green
Characterization of a feedback ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
70
3698-3702
1973
-
-
-
-
-
-
4
3
-
-
-
-
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1
-
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1
-
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1
1
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1
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1
-
-
-
-
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6
-
-
-
-
-
-
-
-
-
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4
6
3
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-
-
-
-
-
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1
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
642717
Fox
Human phosphoribosylpyrophosph ...
Homo sapiens
J. Biol. Chem.
247
2126-2131
1972
1
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-
-
-
-
31
3
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-
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1
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2
-
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1
1
-
1
-
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2
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1
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
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31
3
3
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-
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1
-
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1
-
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
642708
Switzer
Regulation and mechanism of ph ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2
J. Biol. Chem.
244
2854-2863
1969
3
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-
-
-
1
3
9
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5
1
2
-
42
-
-
1
-
-
-
1
1
4
-
1
-
-
-
1
1
-
-
-
-
-
3
-
-
-
-
-
1
-
3
-
9
-
5
1
2
-
-
-
1
-
-
1
1
4
-
1
-
-
-
1
1
-
-
-
-
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-