Application | Comment | Organism |
---|---|---|
medicine | enzyme IP6K1 is a target in obesity and type-2 diabetes | Mus musculus |
Cloned (Comment) | Organism |
---|---|
gene IP6K1, recombinant coexpression of GST-tagged wild-type and mutant enzymes with Myc-tagged PLIN1 in HEK-293 cells, recombinant expression of Myc-tagged enzyme | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S118A/S121A | site-directed mutagenesis, no phosphorylation of IP6K1 mutant S118A-S121A in HEK293 cells. The mutant does not efficiently bind Myc-PLIN1 in HEK293 cells | Mus musculus |
S85A | site-directed mutagenesis, the mutation does not influence its binding to Myc-PLIN1 in HEK293 cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6PD10 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the phosphorylation of IP6K1 at a PKC/PKA motif modulates its interaction with PLIN1 and lipolysis. GST-IP6K1 phosphorylation in HEK293 cells is enhanced by forskolin-mediated PKA activation. Endogenous IP6K1 phosphorylation in HEK293 cells is enhanced to a greater extent by PKC activation compared to PKA activation as evidenced by PMA and FSK treatments. No phosphorylation of IP6K1 mutant S118A-S121A in HEK293 cells | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
inositol hexakisphosphate kinase-1 | - |
Mus musculus |
IP6K1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of inositol hexakisphosphate kinase-1 (IP6K1) protects mice from high fat diet induced obesity and insulin resistance in mice. IP6K1-KO mice are lean due to enhanced energy expenditure. IP6K1-KO mice display enhanced basal lipolysis. IP6K1 modulates lipolysis via its interaction with the lipolytic regulator protein perilipin1 (PLIN1) | Mus musculus |
physiological function | inositol hexakisphosphate kinases (IP6Ks) primarily generate the signaling molecule, inositol diphosphate, 5-IP7. Phosphorylation of IP6K1 at a PKC/PKA motif modulates its interaction with PLIN1 and lipolysis. Enzyme IP6K1 is a regulator of PLIN1 mediated lipolysis. The PKA/PKC phosphorylation motif in IP6K1 regulates its interaction with PLIN1 and lipolysis | Mus musculus |