Literature summary for 2.7.4.1 extracted from

Sanyal, S.; Banerjee, S.; Banerjee, R.; Mukhopadhyay, J.; Kundu, M.
Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E (2013), Microbiology, 159, 2074-2086.

Search for more literature for 2.7.4.1

Cloned(Commentary)

Cloned (Comment)	Organism
gene ppk1, the ppk1 promoter of Mycobacterium tuberculosis is activated under phosphate starvation, involvement of SigE in ppk1 transcription, binding of SigE to the ppk1 promoter. Quantitative RT-PCR ppk1 expression analysis. Gene ppk1 in vitro transcription	Mycobacterium tuberculosis

Protein Variants

Protein Variants	Comment	Organism
additional information	the ppk1 promoter of Mycobacterium tuberculosis is activated under phosphate starvation. This is attenuated upon deletion of an imperfect palindrome likely representing a binding site for the response regulator RegX3, a component of the two-component system SenX3-RegX3 that responds to phosphate starvation. The activity of the ppk1 promoter is abrogated upon deletion of a putative SigE binding site	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	A5YKM2	-	-
Mycobacterium tuberculosis H37Rv	A5YKM2	-	-

Synonyms

Synonyms	Comment	Organism
polyphosphate kinase 1	-	Mycobacterium tuberculosis
PPK1	-	Mycobacterium tuberculosis

Expression

Organism	Comment	Expression
Mycobacterium tuberculosis	overexpression of RseA (anti-SigE) attenuates ppk1 expression under phosphate starvation	down
Mycobacterium tuberculosis	the ppk1 promoter of Mycobacterium tuberculosis is activated under phosphate starvation. Role of RseA in the activation of ppk1 transcription under phosphate depletion	up

General Information

General Information	Comment	Organism
physiological function	polyphosphate kinase 1 is a central node in the stress response network of Mycobacterium tuberculosis, it connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E, overview. Role of SigE in ppk1 transcription, while enzyme PPK1 is itself capable of regulating sigE expression via the MprAB TCS, presence of multiple positive feedback loops in this signalling circuit. Gene ppk1 is induced during phosphate limitation in Mycobacterium tuberculosis	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)