Literature summary for 2.7.4.1 extracted from

Candon, H.L.; Allan, B.J.; Fraley, C.D.; Gaynor, E.C.
Polyphosphate kinase 1 (PPK1) is a pathogenesis determinant in Campylobacter jejuni (2007), J. Bacteriol., 189, 8099-8108.

Search for more literature for 2.7.4.1

Protein Variants

Protein Variants	Comment	Organism
additional information	50% of the wild type gene are deleted, mutants reveal lower level of phosphorylated products and higher suceptibility to environmental stress	Campylobacter jejuni
additional information	generation of a targeted ppk1 deletion mutant in Campylobacter jejuni strain 81-176, which exhibits low levels of polyphosphate at all growth stages in contrast to the wild-type enzyme. The DELTAppk1 mutant is defective for survival during osmotic shock and low-nutrient stress, phenotype, overview	Campylobacter jejuni

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (phosphate)n	Campylobacter jejuni	polyphosphate utilization and accumulation contribute significantly to Campylobacter jejuni pathogenesis and affect its ability to adapt to specific stresses and stringencies	ADP + (phosphate)n+1	-	r
ATP + (phosphate)n	Campylobacter jejuni 81-176	polyphosphate utilization and accumulation contribute significantly to Campylobacter jejuni pathogenesis and affect its ability to adapt to specific stresses and stringencies	ADP + (phosphate)n+1	-	r

Organism

Organism	UniProt	Comment	Textmining
Campylobacter jejuni	A1W0X7	-	-
Campylobacter jejuni	A1W0X7	highly invasive strain 81-176	-
Campylobacter jejuni 81-176	A1W0X7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	wild-type enzyme activity increases significantly as the bacteria transition from log to stationary phase	Campylobacter jejuni	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (phosphate)n	-	Campylobacter jejuni	ADP + (phosphate)n+1	-	r
ATP + (phosphate)n	polyphosphate utilization and accumulation contribute significantly to Campylobacter jejuni pathogenesis and affect its ability to adapt to specific stresses and stringencies	Campylobacter jejuni	ADP + (phosphate)n+1	-	r
ATP + (phosphate)n	-	Campylobacter jejuni 81-176	ADP + (phosphate)n+1	-	r
ATP + (phosphate)n	polyphosphate utilization and accumulation contribute significantly to Campylobacter jejuni pathogenesis and affect its ability to adapt to specific stresses and stringencies	Campylobacter jejuni 81-176	ADP + (phosphate)n+1	-	r

Synonyms

Synonyms	Comment	Organism
ATP:polyphosphate phosphotransferase	-	Campylobacter jejuni
kinase, polyphosphate (phosphorylating)	-	Campylobacter jejuni
polyphosphate kinase	-	Campylobacter jejuni
polyphosphate kinase 1	-	Campylobacter jejuni
PPK	-	Campylobacter jejuni
PPK1	-	Campylobacter jejuni

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Campylobacter jejuni

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Release 2023.1 (January 2023)