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Literature summary for 2.7.2.3 extracted from

  • Rojas-Pirela, M.; Andrade-Alviarez, D.; Rojas, V.; Kemmerling, U.; Caceres, A.J.; Michels, P.A.; Concepcion, J.L.; Quinones, W.
    Phosphoglycerate kinase structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea (2020), Open Biology, 10, 200302 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.2.3

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Corynebacterium glutamicum
ATP isoform PGKC is inhibited at concentrations higher than 0.23 mM ATP Trypanosoma cruzi
Na+ slight inhibition Thermus thermophilus
NaCl the enzyme is negatively affected by NaCl at concentrations above 150 mM; the enzyme is negatively affected by NaCl at concentrations above 150 mM Trypanosoma cruzi
Zn2+ strong inhibition Corynebacterium glutamicum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 ATP wild type enzyme, isoform PGKB, pH and temperature not specified in the publication Trypanosoma cruzi
0.1
-
 ATP wild type enzyme, isoform PGKC, pH and temperature not specified in the publication Trypanosoma cruzi
0.11
-
 ATP pH and temperature not specified in the publication Corynebacterium glutamicum
0.118
-
 ATP pH and temperature not specified in the publication Leishmania major
0.12
-
 ATP isoform PGK-1, pH and temperature not specified in the publication Homo sapiens
0.13
-
 ATP wild type enzyme, pH and temperature not specified in the publication Trypanosoma rangeli
0.13
-
 ATP isoform PGKB, pH and temperature not specified in the publication Leishmania mexicana mexicana
0.16
-
 3-phospho-D-glycerate isoform PGK-2, pH and temperature not specified in the publication Homo sapiens
0.174
-
 3-phospho-D-glycerate wild type enzyme, isoform PGKA, pH and temperature not specified in the publication Trypanosoma cruzi
0.18
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Synechocystis sp. PCC 6803
0.19
-
 ATP pH and temperature not specified in the publication Synechocystis sp. PCC 6803
0.192
-
 3-phospho-D-glycerate wild type enzyme, isoform PGKC, pH and temperature not specified in the publication Trypanosoma cruzi
0.21
-
 ATP wild type enzyme, pH and temperature not specified in the publication Pseudomonas sp. 'TAC II 18'
0.217
-
 ATP wild type enzyme, isoform PGKA, pH and temperature not specified in the publication Trypanosoma cruzi
0.22
-
 3-phospho-D-glycerate isoform PGK-1, pH and temperature not specified in the publication Homo sapiens
0.236
-
 ATP recombinant enzyme, isoform PGKA, pH and temperature not specified in the publication Trypanosoma cruzi
0.24
-
 ATP native enzyme, pH and temperature not specified in the publication Pseudomonas sp. 'TAC II 18'
0.24
-
 ATP isoform PGKB, pH and temperature not specified in the publication Leishmania mexicana mexicana
0.26
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Corynebacterium glutamicum
0.28
-
 ATP pH and temperature not specified in the publication Thermus thermophilus
0.28
-
 3-phospho-D-glycerate wild type enzyme, pH and temperature not specified in the publication Trypanosoma rangeli
0.28
-
 ATP wild type enzyme, isoform PGKC, pH and temperature not specified in the publication Trypanosoma brucei brucei
0.29
-
 ATP recombinant enzyme, isoform PGKC, pH and temperature not specified in the publication Trypanosoma brucei brucei
0.3
-
 ATP pH and temperature not specified in the publication Spinacia oleracea
0.34
-
 ATP isoform PGK-2, pH and temperature not specified in the publication Homo sapiens
0.38
-
 ATP His-tagged recombinant enzyme, pH and temperature not specified in the publication Pseudomonas sp. 'TAC II 18'
0.42
-
 ATP pH and temperature not specified in the publication Oryctolagus cuniculus
0.46
-
 ATP wild type enzyme, isoform PGKB, pH and temperature not specified in the publication Trypanosoma brucei brucei
0.48
-
 ATP pH and temperature not specified in the publication Spirulina geitleri
0.48
-
 ATP pH and temperature not specified in the publication Saccharomyces cerevisiae
0.48
-
 3-phospho-D-glycerate native enzyme, pH and temperature not specified in the publication Pseudomonas sp. 'TAC II 18'
0.5
-
 ATP recombinant enzyme, pH and temperature not specified in the publication Trypanosoma rangeli
0.53
-
 3-phospho-D-glycerate wild type enzyme, pH and temperature not specified in the publication Pseudomonas sp. 'TAC II 18'
0.547
-
 3-phospho-D-glycerate recombinant enzyme, pH and temperature not specified in the publication Entamoeba histolytica
0.62
-
 3-phospho-D-glycerate wild type enzyme, isoform PGKB, pH and temperature not specified in the publication Trypanosoma cruzi
0.661
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Leishmania major
0.71
-
 3-phospho-D-glycerate recombinant enzyme, pH and temperature not specified in the publication Trypanosoma rangeli
0.85
-
 3-phospho-D-glycerate recombinant enzyme, isoform PGKA, pH and temperature not specified in the publication Trypanosoma cruzi
0.89
-
 ATP pH and temperature not specified in the publication Phaeodactylum tricornutum
0.89
-
 3-phospho-D-glycerate His-tagged recombinant enzyme, pH and temperature not specified in the publication Pseudomonas sp. 'TAC II 18'
1.1
-
 ATP pH and temperature not specified in the publication Zymomonas mobilis
1.1
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Spinacia oleracea
1.28
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Saccharomyces cerevisiae
1.37
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Oryctolagus cuniculus
1.439
-
 ATP recombinant enzyme, pH and temperature not specified in the publication Entamoeba histolytica
1.45
-
 3-phospho-D-glycerate isoform PGKB, pH and temperature not specified in the publication Leishmania mexicana mexicana
1.5
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Zymomonas mobilis
1.5
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Spirulina geitleri
1.55
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Phaeodactylum tricornutum
1.55
-
 3-phospho-D-glycerate wild type enzyme, isoform PGKC, pH and temperature not specified in the publication Trypanosoma brucei brucei
1.79
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Thermus thermophilus
2.02
-
 3-phospho-D-glycerate recombinant enzyme, isoform PGKC, pH and temperature not specified in the publication Trypanosoma brucei brucei
2.04
-
 3-phospho-D-glycerate wild type enzyme, isoform PGKB, pH and temperature not specified in the publication Trypanosoma brucei brucei
2.2
-
 3-phospho-D-glycerate pH and temperature not specified in the publication Geobacillus stearothermophilus
2.75
-
 3-phospho-D-glycerate isoform PGKB, pH and temperature not specified in the publication Leishmania mexicana mexicana
2.9
-
 ATP pH and temperature not specified in the publication Geobacillus stearothermophilus
5
-
 ATP wild type enzyme, pH and temperature not specified in the publication Entamoeba histolytica

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Leishmania major 5829
-
cytosol
-
 Entamoeba histolytica 5829
-
cytosol
-
 Trypanosoma rangeli 5829
-
cytosol
-
 Trypanosoma brucei brucei 5829
-
cytosol
-
 Trypanosoma cruzi 5829
-
glycosome
-
 Trypanosoma rangeli 20015
-
glycosome
-
 Trypanosoma brucei brucei 20015
-
glycosome isoform PGKA Trypanosoma cruzi 20015
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+ significantly increases the activity of the enzyme Corynebacterium glutamicum
Mg2+ required for activity Oryctolagus cuniculus
Mg2+ required for activity Geobacillus stearothermophilus
Mg2+ required for activity Spinacia oleracea
Mg2+ required for activity Corynebacterium glutamicum
Mg2+ required for activity Zymomonas mobilis
Mg2+ required for activity Leishmania mexicana mexicana
Mg2+ required for activity Thermotoga maritima
Mg2+ required for activity Phaeodactylum tricornutum
Mg2+ required for activity Synechocystis sp. PCC 6803
Mg2+ required for activity Spirulina geitleri
Mg2+ required for activity Homo sapiens
Mg2+ required for activity Saccharomyces cerevisiae
Mg2+ required for activity Leishmania major
Mg2+ required for activity Pseudomonas sp. 'TAC II 18'
Mg2+ required for activity Thermus thermophilus
Mg2+ required for activity Entamoeba histolytica
Mg2+ required for activity Trypanosoma rangeli
Mg2+ required for activity Trypanosoma brucei brucei
Mg2+ required for activity Trypanosoma cruzi
Na+ significantly increases the activity of the enzyme Corynebacterium glutamicum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
 gel filtration Trypanosoma rangeli
104000
-
 gel filtration Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + 3-phospho-D-glyceroyl phosphate Oryctolagus cuniculus
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Geobacillus stearothermophilus
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Spinacia oleracea
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Corynebacterium glutamicum
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Zymomonas mobilis
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Leishmania mexicana mexicana
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Thermotoga maritima
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Phaeodactylum tricornutum
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Synechocystis sp. PCC 6803
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Spirulina geitleri
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Homo sapiens
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Saccharomyces cerevisiae
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Leishmania major
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Pseudomonas sp. 'TAC II 18'
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Thermus thermophilus
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Entamoeba histolytica
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Trypanosoma rangeli
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Trypanosoma brucei brucei
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Trypanosoma cruzi
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Entamoeba histolytica HM-1:IMSS-A
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Trypanosoma cruzi CL-Brener
-
 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate Trypanosoma rangeli SC58
-
 ATP + 3-phospho-D-glycerate
-
 r
ATP + 3-phospho-D-glycerate Oryctolagus cuniculus
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Geobacillus stearothermophilus
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Spinacia oleracea
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Corynebacterium glutamicum
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Zymomonas mobilis
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Leishmania mexicana mexicana
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Thermotoga maritima
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Phaeodactylum tricornutum
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Synechocystis sp. PCC 6803
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Spirulina geitleri
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Homo sapiens
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Saccharomyces cerevisiae
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Leishmania major
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Pseudomonas sp. 'TAC II 18'
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Thermus thermophilus
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Entamoeba histolytica
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Trypanosoma rangeli
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Trypanosoma brucei brucei
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Trypanosoma cruzi
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Entamoeba histolytica HM-1:IMSS-A
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Trypanosoma cruzi CL-Brener
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate Trypanosoma rangeli SC58
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
-
-
-
Entamoeba histolytica N9V9W5
-
-
Entamoeba histolytica HM-1:IMSS-A N9V9W5
-
-
Geobacillus stearothermophilus
-
-
-
Homo sapiens P00558
-
-
Leishmania major Q27683
-
-
Leishmania mexicana mexicana
-
-
-
Oryctolagus cuniculus
-
-
-
Phaeodactylum tricornutum
-
-
-
Pseudomonas sp. 'TAC II 18' Q9RBS3
-
-
Saccharomyces cerevisiae P00560
-
-
Spinacia oleracea
-
-
-
Spirulina geitleri
-
-
-
Synechocystis sp. PCC 6803
-
-
-
Thermotoga maritima
-
-
-
Thermus thermophilus P09403
-
-
Trypanosoma brucei brucei P07377
-
-
Trypanosoma brucei brucei P07378
-
-
Trypanosoma cruzi Q4D192 isoform PGKA
-
Trypanosoma cruzi Q4D193
-
-
Trypanosoma cruzi CL-Brener Q4D192 isoform PGKA
-
Trypanosoma cruzi CL-Brener Q4D193
-
-
Trypanosoma rangeli A0A061J5A1
-
-
Trypanosoma rangeli A0A061J9D5
-
-
Trypanosoma rangeli SC58 A0A061J5A1
-
-
Trypanosoma rangeli SC58 A0A061J9D5
-
-
Zymomonas mobilis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + 3-phospho-D-glyceroyl phosphate
-
 Oryctolagus cuniculus ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Geobacillus stearothermophilus ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Spinacia oleracea ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Corynebacterium glutamicum ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Zymomonas mobilis ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Leishmania mexicana mexicana ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Thermotoga maritima ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Phaeodactylum tricornutum ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Synechocystis sp. PCC 6803 ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Spirulina geitleri ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Homo sapiens ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Saccharomyces cerevisiae ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Leishmania major ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Pseudomonas sp. 'TAC II 18' ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Thermus thermophilus ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Entamoeba histolytica ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Trypanosoma rangeli ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Trypanosoma brucei brucei ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Trypanosoma cruzi ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Entamoeba histolytica HM-1:IMSS-A ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Trypanosoma cruzi CL-Brener ATP + 3-phospho-D-glycerate
-
 r
ADP + 3-phospho-D-glyceroyl phosphate
-
 Trypanosoma rangeli SC58 ATP + 3-phospho-D-glycerate
-
 r
ATP + 3-phospho-D-glycerate
-
 Oryctolagus cuniculus ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Geobacillus stearothermophilus ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Spinacia oleracea ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Corynebacterium glutamicum ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Zymomonas mobilis ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Leishmania mexicana mexicana ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Thermotoga maritima ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Phaeodactylum tricornutum ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Synechocystis sp. PCC 6803 ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Spirulina geitleri ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Homo sapiens ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Saccharomyces cerevisiae ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Leishmania major ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Pseudomonas sp. 'TAC II 18' ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Thermus thermophilus ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Entamoeba histolytica ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Trypanosoma rangeli ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Trypanosoma brucei brucei ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Trypanosoma cruzi ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Entamoeba histolytica HM-1:IMSS-A ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Trypanosoma cruzi CL-Brener ADP + 3-phospho-D-glyceroyl phosphate
-
 r
ATP + 3-phospho-D-glycerate
-
 Trypanosoma rangeli SC58 ADP + 3-phospho-D-glyceroyl phosphate
-
 r

Subunits

Subunits Comment Organism
homodimer
-
 Corynebacterium glutamicum
monomer
-
 Thermotoga maritima
monomer
-
 Synechocystis sp. PCC 6803
monomer
-
 Spirulina geitleri
monomer
-
 Homo sapiens
monomer 1 * 62000, SDS-PAGE Leishmania major
monomer 1 * 45000, SDS-PAGE Phaeodactylum tricornutum
monomer 1 * 47000, SDS-PAGE Oryctolagus cuniculus
monomer 1 * 46000, SDS-PAGE Spinacia oleracea
monomer 1 * 42000, SDS-PAGE Geobacillus stearothermophilus
monomer 1 * 44000, SDS-PAGE Zymomonas mobilis
monomer 1 * 44000, SDS-PAGE Trypanosoma rangeli
monomer 1 * 40100, SDS-PAGE Pseudomonas sp. 'TAC II 18'
monomer 1 * 44600, calculated from amino acid sequence Thermus thermophilus
monomer 1 * 45000, isoform PGKB, SDS-PAGE Trypanosoma brucei brucei
monomer 1 * 47000, isoform PGKB, SDS-PAGE Leishmania mexicana mexicana
monomer 1 * 47000, isoform PGKB, SDS-PAGE Trypanosoma cruzi
monomer 1 * 47000, isoform PGKC, SDS-PAGE Trypanosoma brucei brucei
monomer 1 * 47100, calculated from amino acid sequence Saccharomyces cerevisiae
monomer 1 * 48000, isoform PGKC, SDS-PAGE Trypanosoma cruzi
monomer 1 * 48400, SDS-PAGE Entamoeba histolytica
monomer 1 * 53000, isoform PGKC, SDS-PAGE Leishmania mexicana mexicana
monomer 1 * 56000, isoform PGKA, SDS-PAGE Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Oryctolagus cuniculus
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Geobacillus stearothermophilus
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Spinacia oleracea
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Corynebacterium glutamicum
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Zymomonas mobilis
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Leishmania mexicana mexicana
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Thermotoga maritima
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Phaeodactylum tricornutum
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Synechocystis sp. PCC 6803
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Spirulina geitleri
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Homo sapiens
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Saccharomyces cerevisiae
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Leishmania major
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Pseudomonas sp. 'TAC II 18'
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Thermus thermophilus
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Entamoeba histolytica
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Trypanosoma rangeli
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Trypanosoma brucei brucei
ATP:3-phospho-D-glycerate 1-phosphotransferase
-
 Trypanosoma cruzi
PAS-PGK
-
 Leishmania major
PGK
-
 Oryctolagus cuniculus
PGK
-
 Geobacillus stearothermophilus
PGK
-
 Spinacia oleracea
PGK
-
 Corynebacterium glutamicum
PGK
-
 Zymomonas mobilis
PGK
-
 Thermotoga maritima
PGK
-
 Synechocystis sp. PCC 6803
PGK
-
 Spirulina geitleri
PGK
-
 Saccharomyces cerevisiae
PGK
-
 Pseudomonas sp. 'TAC II 18'
PGK
-
 Thermus thermophilus
PGK
-
 Entamoeba histolytica
PGK-1 isoform Homo sapiens
PGK-2 isoform Homo sapiens
PGKA isoform Trypanosoma cruzi
PGKase-1
-
 Phaeodactylum tricornutum
PGKB
-
 Trypanosoma rangeli
PGKB isoform Leishmania mexicana mexicana
PGKB isoform Trypanosoma brucei brucei
PGKB isoform Trypanosoma cruzi
PGKC isoform Leishmania mexicana mexicana
PGKC isoform Trypanosoma brucei brucei
PGKC isoform Trypanosoma cruzi

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
100
-
 the enzyme has a half-life of irreversible thermal inactivation of 2 h at 100°C Thermotoga maritima

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Leishmania major
5.5
-
 isoform PGKB Trypanosoma cruzi
8
-
-
 Pseudomonas sp. 'TAC II 18'
8
-
 isoform PGKA Trypanosoma cruzi

pH Range

pH Minimum pH Maximum Comment Organism
5 7
-
 Entamoeba histolytica
5.5 8.5
-
 Geobacillus stearothermophilus
6 9 isoform PGKB Trypanosoma brucei brucei
6 8.5
-
 Thermus thermophilus
6 9.2
-
 Oryctolagus cuniculus
6 9.2
-
 Saccharomyces cerevisiae
6.5 9.5
-
 Spinacia oleracea
7 7.4
-
 Corynebacterium glutamicum
8 10
-
 Trypanosoma rangeli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1
-
 ADP pH and temperature not specified in the publication Corynebacterium glutamicum
0.27
-
 ATP isoform PGKC, pH and temperature not specified in the publication Trypanosoma cruzi
0.45
-
 Zn2+ pH and temperature not specified in the publication Corynebacterium glutamicum

pI Value

Organism Comment pI Value Maximum pI Value
Spinacia oleracea calculated from amino acid sequence
-
 4.3
Spirulina geitleri calculated from amino acid sequence
-
 4.8
Geobacillus stearothermophilus calculated from amino acid sequence
-
 4.9
Pseudomonas sp. 'TAC II 18' calculated from amino acid sequence
-
 4.9
Thermus thermophilus calculated from amino acid sequence
-
 5
Trypanosoma brucei brucei isoform PGKB, calculated from amino acid sequence
-
 6.3
Trypanosoma cruzi isoform PGKB, calculated from amino acid sequence
-
 6.6
Entamoeba histolytica calculated from amino acid sequence
-
 6.7
Oryctolagus cuniculus calculated from amino acid sequence
-
 7
Trypanosoma cruzi isoform PGKA, calculated from amino acid sequence
-
 7
Saccharomyces cerevisiae calculated from amino acid sequence
-
 7.2
Leishmania major calculated from amino acid sequence
-
 8.8
Trypanosoma brucei brucei isoform PGKC, calculated from amino acid sequence
-
 9.3