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Literature summary for 2.7.2.3 extracted from

  • Qian, X.; Li, X.; Cai, Q.; Zhang, C.; Yu, Q.; Jiang, Y.; Lee, J.H.; Hawke, D.; Wang, Y.; Xia, Y.; Zheng, Y.; Jiang, B.H.; Liu, D.X.; Jiang, T.; Lu, Z.
    Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy (2017), Mol. Cell, 65, 917-931.e6 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.2.3

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 5 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 3-phospho-D-glycerate Homo sapiens
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
ATP + Beclin1 Homo sapiens
-
 ADP + Ser30-phosphorylated Beclin1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00558
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
U-251MG cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
 Homo sapiens ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
ATP + Beclin1
-
 Homo sapiens ADP + Ser30-phosphorylated Beclin1
-
 ?

Synonyms

Synonyms Comment Organism
PGK1
-
 Homo sapiens
phosphoglycerate kinase 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function phosphoglycerate kinase 1 phosphorylates Beclin1 at Ser30 to enhance phosphatidylinositol 3-kinase VPS34 activity and to induce autophagy which is instrumental for brain tumor development Homo sapiens