BRENDA - Enzyme Database
show all sequences of 2.7.11.9

Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development

Granero-Molto, F.; Sarmah, S.; ORear, L.; Spagnoli, A.; Abrahamson, D.; Saus, J.; Hudson, B.G.; Knapik, E.W.; J. Biol. Chem. 283, 20495-20504 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBPDELTA26 in HEK-293 cells; gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBP in HEK-293 cells
Danio rerio
Engineering
Amino acid exchange
Commentary
Organism
additional information
construction of antisense oligonucleotide-mediated loss-of-function and synthetic mRNA-based gain-of-function mutants. The loss-of-function phenotype is linked to cell death, evident primarily in the muscle of the somites, extensive loss of myelinated tracks, and brain edema, phenotype, overview
Danio rerio
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [Goodpasture antigen-binding protein]
Danio rerio
the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
?
additional information
Danio rerio
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Danio rerio
Q5M7Y0
GPBPDELTA26; gene COL4A3BP; GPBP; gene COL4A3BP
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, GPBP is an important factor for normal skeletal muscle and brain development, overview; isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, overview
Danio rerio
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [Goodpasture antigen-binding protein]
the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV
693093
Danio rerio
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
?
additional information
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
693093
Danio rerio
?
-
-
-
-
additional information
isozyme GPBP also function as ceramide transfer proteins, CERT
693093
Danio rerio
?
-
-
-
-
additional information
isozyme GPBPDELTA26 also functions as ceramide transfer protein, CERT
693093
Danio rerio
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Danio rerio
Cloned(Commentary) (protein specific)
Commentary
Organism
gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBPDELTA26 in HEK-293 cells; gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBP in HEK-293 cells
Danio rerio
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Danio rerio
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
construction of antisense oligonucleotide-mediated loss-of-function and synthetic mRNA-based gain-of-function mutants. The loss-of-function phenotype is linked to cell death, evident primarily in the muscle of the somites, extensive loss of myelinated tracks, and brain edema, phenotype, overview
Danio rerio
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [Goodpasture antigen-binding protein]
Danio rerio
the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
?
additional information
Danio rerio
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, GPBP is an important factor for normal skeletal muscle and brain development, overview; isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, overview
Danio rerio
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [Goodpasture antigen-binding protein]
the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV
693093
Danio rerio
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
?
additional information
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
693093
Danio rerio
?
-
-
-
-
additional information
isozyme GPBP also function as ceramide transfer proteins, CERT
693093
Danio rerio
?
-
-
-
-
additional information
isozyme GPBPDELTA26 also functions as ceramide transfer protein, CERT
693093
Danio rerio
?
-
-
-
-
Other publictions for EC 2.7.11.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Goodpasture antigen-binding pr ...
Danio rerio
J. Biol. Chem.
283
20495-20504
2008
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693162
Revert
Goodpasture antigen-binding pr ...
Homo sapiens
J. Biol. Chem.
283
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2008
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2005
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1
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1
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275
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2000
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1
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1
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491669
Raya
Characterization of a novel ty ...
Homo sapiens
J. Biol. Chem.
274
12642-12649
1999
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1
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1
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