Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin A | activates Cdk2 | Xenopus laevis | |
cyclin B | activates CDK1 | Xenopus laevis | |
cyclin E | activates Cdk2 | Xenopus laevis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acidic alpha-syntrophin protein | substrate of cyclinA/CDK2, not of cyclin E/CDK2 | Xenopus laevis | ADP + acidic alpha-syntrophin phosphoprotein | - |
? | |
ATP + ADP-ribosylation factor GTPase activating protein 3 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + ADP-ribosylation factor GTPase activating protein 3 phosphoprotein | - |
? | |
ATP + AE binding protein 2 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + AE binding protein 2 phosphoprotein | - |
? | |
ATP + APEX nuclease protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + APEX nuclease phosphoprotein | - |
? | |
ATP + ARAF serine/threonine protein kinase protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + ARAF serine/threonine protein kinase phosphoprotein | - |
? | |
ATP + ATRIP protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + ATRIP phosphoprotein | - |
? | |
ATP + cAMP responsive element binding protein 3-like 2 protein | substrate of cyclinA/CDK2, not of cyclin E/CDK2 | Xenopus laevis | ADP + cAMP responsive element binding protein 3-like 2 phosphoprotein | - |
? | |
ATP + CCAAT/enhancer binding protein gamma protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + CCAAT/enhancer binding protein gamma phosphoprotein | - |
? | |
ATP + coiled-coil domain protein 52 protein | substrate of cyclin E/CDK2, not of cyclinA/CDK2 | Xenopus laevis | ADP + coiled-coil domain protein 52 phosphoprotein | - |
? | |
ATP + CPEB-associated factor Maskin protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + CPEB-associated factor Maskin phosphoprotein | - |
? | |
ATP + diacylglycerol kinase epsilon protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + diacylglycerol kinase epsilon phosphoprotein | - |
? | |
ATP + diphthamide biosynthesis protein 2 isoform a protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + diphthamide biosynthesis protein 2 isoform a phosphoprotein | - |
? | |
ATP + distal-less homeobox 1 isoform 1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + distal-less homeobox 1 isoform 1 phosphoprotein | - |
? | |
ATP + Erp1/emi2 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + Erp1/emi2 phosphoprotein | - |
? | |
ATP + establishment of cohesion-1 homologue 2 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + establishment of cohesion-1 homologue 2 phosphoprotein | - |
? | |
ATP + ETS variant gene-1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + ETS variant gene-1 phosphoprotein | - |
? | |
ATP + Fizzy1 protein | substrate of cyclin E/CDK2, not of cyclinA/CDK2 | Xenopus laevis | ADP + Fizzy1 phosphoprotein | - |
? | |
ATP + glycogenin protein | substrate of cyclin B/CDK1, not of cyclinA/CDK2 | Xenopus laevis | ADP + glycogenin phosphoprotein | - |
? | |
ATP + granulin isoform 1 precursor protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + granulin isoform 1 precursor phosphoprotein | - |
? | |
ATP + heat shock transcription factor 1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + heat shock transcription factor 1 phosphoprotein | - |
? | |
ATP + Hermes protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + Hermes phosphoprotein | - |
? | |
ATP + histone deacetylase 6 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + histone deacetylase 6 phosphoprotein | - |
? | |
ATP + histone stem-loop binding protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + histone stem-loop binding phosphoprotein | - |
? | |
ATP + Kunitz type serine protease inhibitor 2 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + Kunitz type serine protease inhibitor 2 phosphoprotein | - |
? | |
ATP + lamina-associated protein 2-beta isoform protein | substrate of cyclinA/CDK2, not of cyclin E/CDK2 | Xenopus laevis | ADP + lamina-associated protein 2-beta isoform phosphoprotein | - |
? | |
ATP + LOC222229 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + LOC222229 phosphoprotein | - |
? | |
ATP + low density lipoprotein receptor adaptor protein 1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + low density lipoprotein receptor adaptor protein 1 phosphoprotein | - |
? | |
ATP + MAP/microtubule affinity regulating kinase 3 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + MAP/microtubule affinity regulating kinase 3 phosphoprotein | - |
? | |
ATP + maternal embryonic leucine zipper kinase protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + maternal embryonic leucine zipper kinase phosphoprotein | - |
? | |
ATP + MGC86234 protein | i.e. potassium channel tetramerisation domaincontaining 3, substrate of cyclinA/CDK2, not of cyclin E/CDK2 | Xenopus laevis | ADP + MGC86234 phosphoprotein | - |
? | |
ATP + minor histocompatibility antigen HA-1 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + minor histocompatibility antigen HA-1 phosphoprotein | - |
? | |
ATP + palmitoylated membrane protein 1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + palmitoylated membrane protein 1 phosphoprotein | - |
? | |
ATP + PASCIN protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + PASCIN phosphoprotein | - |
? | |
ATP + phosphatidylinositol-4-phosphate 5-kinase type IIba protein | substrate of cyclinA/CDK2, not of cyclin E/CDK2 | Xenopus laevis | ADP + phosphatidylinositol-4-phosphate 5-kinase type IIba phosphoprotein | - |
? | |
ATP + PIF1 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + PIF1 phosphoprotein | - |
? | |
ATP + POM21 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + POM21 phosphoprotein | - |
? | |
ATP + pre-B-cell leukemia transcription factor 1 protein | substrate of cyclinA/CDK2, not of cyclin B/CDK1 | Xenopus laevis | ADP + pre-B-cell leukemia transcription factor 1 phosphoprotein | - |
? | |
ATP + RNA polymerase 1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + RNA polymerase 1 phosphoprotein | - |
? | |
ATP + SEC14-like 1 isoform a protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + SEC14-like 1 isoform a phosphoprotein | - |
? | |
ATP + semaphorin 6D protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + semaphorin 6D phosphoprotein | - |
? | |
ATP + similar to bicaudal C homologue 1 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + similar to bicaudal C homologue 1 phosphoprotein | - |
? | |
ATP + similar to peroxisomal biogenesis factor 5 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + similar to peroxisomal biogenesis factor 5 phosphoprotein | - |
? | |
ATP + similar to Trigger of mitotic entry 1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + similar to Trigger of mitotic entry 1 phosphoprotein | - |
? | |
ATP + similar to Zinc finger protein 516 protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + similar to Zinc finger protein 516 phosphoprotein | - |
? | |
ATP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 phosphoprotein | - |
? | |
ATP + SmcX-Jumonji/ARID domain-containing protein 1C protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + SmcX-Jumonji/ARID domain-containing protein 1C phosphoprotein | - |
? | |
ATP + striatin protein | substrate of cyclin E/CDK2, not of cyclinA/CDK2 | Xenopus laevis | ADP + striatin phosphoprotein | - |
? | |
ATP + TATA box-binding protein-associated factor 2F protein | substrate of cyclin B/CDK1, not of cyclinA/CDK2 | Xenopus laevis | ADP + TATA box-binding protein-associated factor 2F phosphoprotein | - |
? | |
ATP + telomeric repeat binding factor 2 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + telomeric repeat binding factor 2 phosphoprotein | - |
? | |
ATP + Tipin protein | substrate of cyclinA/CDK2 and cyclin E/CDK2 | Xenopus laevis | ADP + Tipin phosphoprotein | - |
? | |
ATP + v-raf murine sarcoma viral oncogene homolog B1 protein | substrate of cyclin B/CDK1 and cyclinA/CDK2 | Xenopus laevis | ADP + v-raf murine sarcoma viraloncogene homolog B1 phosphoprotein | - |
? | |
ATP + Xenopus laevis protein associated with PRK1 protein | substrate of cyclinA/CDK2, not of cyclin E/CDK2 | Xenopus laevis | ADP + Xenopus laevis protein associated with PRK1 phosphoprotein | - |
? | |
ATP + zinc finger protein 46 protein | substrate of cyclinA/CDK2, not of cyclin E/CDK2 | Xenopus laevis | ADP + zinc finger protein 46 phosphoprotein | - |
? | |
additional information | identification 35 substrates from screening for cyclin B/CDK1, and investigation of the differential specificity of cyclin B/CDK1 versus cyclin A/CDK1 and cyclin A/CDK2. About half the substrates are equally well phosphorylated regardless of the cyclin or the CDK, computational analysis, overview | Xenopus laevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk1 | - |
Xenopus laevis |
CDK2 | - |
Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Xenopus laevis |