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Literature summary for 2.7.11.22 extracted from

  • Chen, R.; Wierda, W.G.; Chubb, S.; Hawtin, R.E.; Fox, J.A.; Keating, M.J.; Gandhi, V.; Plunkett, W.
    Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia (2009), Blood, 113, 4637-4645.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
SNS-032 formerly known as BMS-387032, SNS-032 exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chronic lymphocytic leukemia cell
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + C-terminal domain of RNA polymerase II Cdk7 phosphorylates Ser-5 in the heptad repeats of the C-terminal domain of RNA polymerase II, Cdk9 phosphorylates Ser-2 in the C-terminal domain of RNA RNA polymerase II Homo sapiens ADP + phosphorylated C-terminal domain of RNA polymerase II
-
 ?

Synonyms

Synonyms Comment Organism
CDK2
-
 Homo sapiens
cdk7
-
 Homo sapiens
CDK9
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
cyclin
-
 Homo sapiens