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Literature summary for 2.7.11.17 extracted from
- Calcium/calmodulin-dependent kinases are involved in growth, thermotolerance, oxidative stress survival, and fertility in Neurospora crassa (2014), Arch. Microbiol., 196, 295-305.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene camk-1, sequence comparisons and phylogenetic analysis | Neurospora crassa |
| gene camk-2, sequence comparisons and phylogenetic analysis | Neurospora crassa |
| gene camk-3, sequence comparisons and phylogenetic analysis | Neurospora crassa |
| gene camk-4, sequence comparisons and phylogenetic analysis | Neurospora crassa |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of diverse single and double deletion mutants of genes camk-1-camk-4, phenotypes with reduced thermotolerance and increased sensitivity to oxidative stress, complementation studies with other camk genes, overview, Mutant DELTAcamk-2 shows increased thermotolerance, while all other camk mutants show decreased thermotolerance | Neurospora crassa |
| additional information | generation of diverse single and double deletion mutants of genes camk-1-camk-4, phenotypes with reduced thermotolerance and increased sensitivity to oxidative stress, complementation studies with other camk genes, overview. Mutant DELTAcamk-2 shows increased thermotolerance, while all other camk mutants show decreased thermotolerance | Neurospora crassa |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | a ubiquitous Ca2+-sensing protein called calmodulin (CaM), which contains four EF-hand Ca2+-binding motifs, undergoes conformational change upon Ca2+-binding, and the resulting Ca2+/CaM complex regulates a number of effector proteins including Ca2+/CaM-dependent protein kinases (Ca2+/CaMKs) | Neurospora crassa |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neurospora crassa | Q7RVS8 | - |
- |
| Neurospora crassa | Q7SBJ3 | - |
- |
| Neurospora crassa | V5IPS5 | - |
- |
| Neurospora crassa | V5IQT6 | - |
- |
| Neurospora crassa ATCC 24698 | Q7RVS8 | - |
- |
| Neurospora crassa ATCC 24698 | Q7SBJ3 | - |
- |
| Neurospora crassa ATCC 24698 | V5IPS5 | - |
- |
| Neurospora crassa ATCC 24698 | V5IQT6 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Neurospora crassa | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca/CaM-dependent kinase-1 | - |
Neurospora crassa |
| Ca2+/CaMK | - |
Neurospora crassa |
| calcium/calmodulin-dependent kinase | - |
Neurospora crassa |
| camk-1 | - |
Neurospora crassa |
| Camk-2 | - |
Neurospora crassa |
| camk-3 | - |
Neurospora crassa |
| camk-4 | - |
Neurospora crassa |
| NCU02283 | - |
Neurospora crassa |
| NCU06177 | - |
Neurospora crassa |
| NCU09123 | - |
Neurospora crassa |
| NCU09212 | - |
Neurospora crassa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | a ubiquitous Ca2+-sensing protein called calmodulin (CaM), which contains four EF-hand Ca2+-binding motifs, undergoes conformational change upon Ca2+-binding, and the resulting Ca2+/CaM complex regulates a number of effector proteins including Ca2+/CaM-dependent protein kinases (Ca2+/CaMKs) | Neurospora crassa | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the DELTAcamk-1/DELTAcamk-2, DELTAcamk-4/DELTAcamk-2, and DELTAcamk-3/DELTAcamk-2 double mutants display slow growth phenotype, reduced aerial hyphae, decreased thermotolerance, and increased sensitivity to oxidative stress, revealing the genetic interactions among these kinases | Neurospora crassa |
| malfunction | the survival of DELTAcamk-2 mutant is increased in induced thermotolerance and oxidative stress conditions. The DELTAcamk-1/DELTAcamk-2, DELTAcamk-4/DELTAcamk-2, and DELTAcamk-3/DELTAcamk-2 double mutants display slow growth phenotype, reduced aerial hyphae, decreased thermotolerance, and increased sensitivity to oxidative stress, revealing the genetic interactions among these kinases | Neurospora crassa |
| physiological function | camk-1 is essential for growth, circadian clock, and full fertility in Neurospora crassa playing a recessive role in sexual development. The Ca2+/CaMK isozymes are involved in growth, thermotolerance, oxidative stress tolerance, and fertility in Neurospora crassa | Neurospora crassa |
| physiological function | camk-2 is essential for full fertility in Neurospora crassa playing a recessive role in sexual development. The Ca2+/CaMK isozymes are involved in growth, thermotolerance, oxidative stress tolerance, and fertility in Neurospora crassa | Neurospora crassa |
| physiological function | the Ca2+/CaMK isozymes are involved in growth, thermotolerance, oxidative stress tolerance, and fertility in Neurospora crassa | Neurospora crassa |
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