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Literature summary for 2.7.11.17 extracted from

  • Coultrap, S.J.; Buard, I.; Kulbe, J.R.; DellAcqua, M.L.; Bayer, K.U.
    CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin (2010), J. Biol. Chem., 285, 17930-17937.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ generation of Ca2+-independent autonomous activity by Thr286 autophosphorylation. Autonomy greater than 15–25% is the exception, not the rule, and requires a special mechanism (T-site binding by the T-substrates peptides AC2 or NR2B). Autonomous activity toward regular substrates (including tyrosine hydroxylase and integral membrane protein GluR1) is significantly further stimulated by Ca2+/calmodulin, both in vitro and within cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus generation of Ca2+-independent activity after Thr286 autophosphorylation is a vital step in regulating synaptic plasticity and learning and memory. The autonomy is substrate-dependent, and low autonomy (15-25%) is the general default ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein generation of Ca2+-independent autonomous activity by Thr286 autophosphorylation. Autonomy greater than 15-25% is the exception, not the rule, and requires a special mechanism (T-site binding by the T-substrates peptides AC2 or NR2B). Autonomous activity toward regular substrates (including tyrosine hydroxylase and integral membrane protein GluR1) is significantly further stimulated by Ca2+/calmodulin, both in vitro and within cells. Altered Km and Vmax made autonomy also substrate- (and ATP) concentration-dependent, but only over a narrow range, with remarkable stability at physiological concentrations. Such regulation still allows molecular memory of previous Ca2+ signals, but prevents complete uncoupling from subsequent cellular stimulation Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + peptide AC2 Ca2+-independent autonomous activity after Thr286 autophosphorylation is65% of maximal stimulated activity Mus musculus ADP + phosphorylated peptides AC2
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 ?
ATP + syntide2 Ca2+-independent autonomous activity after Thr286 autophosphorylation is25% of maximal stimulated activity Mus musculus ADP + phosphorylated syntide2
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 ?
additional information generation of Ca2+-independent activity after Thr286 autophosphorylation is a vital step in regulating synaptic plasticity and learning and memory. The autonomy is substrate-dependent, and low autonomy (15-25%) is the general default Mus musculus ?
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 ?
additional information generation of Ca2+-independent autonomous activity by Thr286 autophosphorylation Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
CaMKII
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 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mus musculus

General Information

General Information Comment Organism
physiological function generation of Ca2+-independent activity after Thr286 autophosphorylation is a vital step in regulating synaptic plasticity and learning and memory Mus musculus