Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Notch1 protein | Mus musculus | phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation | ADP + phosphorylated Notch1 protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P08414 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Notch1 protein | - |
Mus musculus | ADP + phosphorylated Notch1 protein | - |
? | |
ATP + Notch1 protein | phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation | Mus musculus | ADP + phosphorylated Notch1 protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase IV | - |
Mus musculus |
CaMKIV | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | calcium/calmodulin-dependent protein kinase IV enhances osteoclast differentiation via the up-regulation of Notch1 protein stability | Mus musculus |