Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-O-tetradecanoyl phorbol 13-acetate | the activating effect is blocked by EGTA | Rattus norvegicus | |
Calmodulin | dependent on | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
overexpression of CaMKII isozyme alpha and truncated mutant CaMKII/290 in PC-12 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of CaMKII favors the Dp71d nuclear accumulation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN62 | a CaMKII-specific inhibitor | Rattus norvegicus | |
N-(6-aminohexyl)-1-naphthalenesulfonamide | i.e. W7, a calcium-calmodulin inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization | Rattus norvegicus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, stimulation of calcium influx by cell depolarization increases Dp71d phosphorylation | Rattus norvegicus | |
KCl | KCl-induced cell depolarization stimulates Dp71d phosphorylation | Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dystrophin Dp71d | Rattus norvegicus | the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization | ADP + phosphorylated dystrophin Dp71d | - |
? | |
additional information | Rattus norvegicus | CaMKII kinase modulates PC12 cell neuronal differentiation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-12 cell | a pheochromocytoma cell line, NGF-induced | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dystrophin Dp71d | the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization | Rattus norvegicus | ADP + phosphorylated dystrophin Dp71d | - |
? | |
ATP + dystrophin Dp71d | a nuclear splicing isoform of Dp71, several potential sites for phosphorylation | Rattus norvegicus | ADP + phosphorylated dystrophin Dp71d | - |
? | |
additional information | CaMKII kinase modulates PC12 cell neuronal differentiation | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ca2+/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
CaMKII | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |