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Literature summary for 2.7.11.17 extracted from

  • Wagner, S.; Dybkova, N.; Rasenack, E.C.; Jacobshagen, C.; Fabritz, L.; Kirchhof, P.; Maier, S.K.; Zhang, T.; Hasenfuss, G.; Brown, J.H.; Bers, D.M.; Maier, L.S.
    Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels (2006), J. Clin. Invest., 116, 3127-3138.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
transient and stable overexpression of isozyme CaMKIIdelta in rabbit and mouse ventricular myocytes leading to a Ca2+-depdnent shift in voltage dependence of Na+ channel availability, enhanced intermediate inactivation, and slowed recovery from inactivation Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information transgenic CaMKIIdelta overexpression prolongs QRS duration and repolarization, i.e. QT intervals, decreases effective refractory periods, and increases the propensity to develop ventricular tachyarrhythmia, overview, CaMKIIdelta enhances steady-state inactivation of transgenic rabbit myocyte sodium current INa, steady-state inactivation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
KN93 reversible inhibition of CaMKII Mus musculus
peptide AIP i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a reversible CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isozyme CaMKIIdelta Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Na+-channel Mus musculus isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview ADP + phosphorylated Na+-channel
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
myocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Na+-channel
-
 Mus musculus ADP + phosphorylated Na+-channel
-
 ?
ATP + Na+-channel isozyme CaMKIIdelta increases persistent/late inward INa and intracellular Na+ concentration regulazing Na+ channel activity, CaMKII expression is increased in heart failure and may be involved in Na+ channel regulation alterations via calmodulin, overview Mus musculus ADP + phosphorylated Na+-channel
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase
-
 Mus musculus
CaMKII
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus