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Literature summary for 2.7.11.17 extracted from
- Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis (2007), Cardiovasc. Res., 73, 648-656.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | dependent on | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KN-93 | - |
Rattus norvegicus | |
| additional information | Ca2+ binds to the autoregulatory region of the enzyme disrupting autoinhibitory interactions and allowing access to the catalytic site for substrate and ATP | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| sarcoplasmic reticulum | - |
Rattus norvegicus | 16529 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on, binds to the autoregulatory region of the enzyme disrupting autoinhibitory interactions | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + NHE-1 | Rattus norvegicus | phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger | ADP + phosphorylated NHE-1 | - |
? | |
| ATP + PLN | Rattus norvegicus | phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition | ADP + phosphorylated PLN | - |
? | |
| additional information | Rattus norvegicus | CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiomyocyte | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + NHE-1 | phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger | Rattus norvegicus | ADP + phosphorylated NHE-1 | - |
? | |
| ATP + NHE-1 | a Na+-H+-exchanging protein, phosphorylation by CaMKII at the intracellular cytoplasmic domain | Rattus norvegicus | ADP + phosphorylated NHE-1 | - |
? | |
| ATP + PLN | phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition | Rattus norvegicus | ADP + phosphorylated PLN | - |
? | |
| ATP + PLN | a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17 | Rattus norvegicus | ADP + phosphorylated PLN | - |
? | |
| additional information | CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| oligomer | CaMKII is a multimeric holoenzyme composed of six to twelve subunits encoded by 4 separate genes | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CaMKII | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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