Activating Compound | Comment | Organism | Structure |
---|---|---|---|
G protein betagamma-subunit | required for maximum activity, targets beta-ARK 1 to the membrane, which presumably facilitates the precise orchestration of phosphorylation of only activated receptors | Mus musculus |
Cloned (Comment) | Organism |
---|---|
cloning and disruption of the beta-ARK 1 gene by homologous recombination, effects of gene disruption on the embryos | Mus musculus |
studies with beta-ARK 1 knockout mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | G protein betagamma-subunit targets beta-ARK 1 to the membrane | Mus musculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
Western blot analysis | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | involved in the regulation of G protein-coupled receptor function, beta-ARK 1 appears to be the predominant GRK in early embryogenesis and plays a fundamental role in cardiac development, enzyme participates in intracellular signal transduction mechanisms, which regulate cardiogenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
beta-ARK 1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | whole embryo extract | Mus musculus | - |
heart | adult heart | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | - |
Mus musculus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + rhodopsin | light-dependent, actual substrate: light-bleached rhodopsin | Mus musculus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | in form of bovine rod outer segments | Mus musculus | ADP + phosphorhodopsin | - |
? | |
additional information | involved in the regulation of G protein-coupled receptor function, beta-ARK 1 appears to be the predominant GRK in early embryogenesis and plays a fundamental role in cardiac development, enzyme participates in intracellular signal transduction mechanisms, which regulate cardiogenesis | Mus musculus | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |