Literature summary for 2.7.11.10 extracted from

Siddiqui, M.A.; Badruddeen, M.A.; Akhtar, J.; Uddin M S, S.; Irfan Khan, M.; Khalid, M.
Molecular mechanism of interactions between chrysin and I-kappa-B kinase epsilon (IKKe)/tank binding kinase-1(TBK1) Cell-based assay and in silico molecular docking studies (2020), J. Biomol. Struct. Dyn., 38, 589-596 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
chrysin	chrysin interacts weakly with the I-kappa-B kinase epsilon binding site and inhibits the enzyme at doses higher than 0.06 mM	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [IkappaB protein]	Homo sapiens	-	ADP + [IkappaB phosphoprotein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14164	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [IkappaB protein]	-	Homo sapiens	ADP + [IkappaB phosphoprotein]	-	?

Synonyms

Synonyms	Comment	Organism
I-kappa-B kinase epsilon	-	Homo sapiens
IKKe	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	I-kappa-B kinase epsilon expression is induced by polyinosinic-polycytidylic acid	up

General Information

General Information	Comment	Organism
physiological function	the enzyme is responsible for production of pro inflammatory cytokine and suppression of energy expenditure genes, finally causing insulin resistance and obesity	Homo sapiens

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Release 2023.1 (January 2023)