Application | Comment | Organism |
---|---|---|
medicine | IKK is thought to be a focal target of drug development | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
Flag-IKKalpha and Flag-IKKbeta vectors for transfection of HEK293 cells are used | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
noraristeromycin | NAM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + NF-kappaB p65 subunit | IKKalpha and IKKbeta phosphorylate NF-kappaB p65 subunit at Ser536 | Homo sapiens | ADP + phosphorylated NF-kappaB p65 subunit | - |
? | |
ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | IKK is a large molecular weight complex consisting of at least two catalytic subunits, IKKalpha, IKKbeta, and the associated regulatory subunit IKKgamma, NEMO | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
IkappaB kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00037 | - |
IKKalpha | Homo sapiens | noraristeromycin | |
0.00064 | - |
inhibited endogenous IKK activity following TNF-alpha stimulation | Homo sapiens | noraristeromycin |