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Literature summary for 2.7.11.10 extracted from

  • Wietek, C.; Cleaver, C.S.; Ludbrook, V.; Wilde, J.; White, J.; Bell, D.J.; Lee, M.; Dickson, M.; Ray, K.P.; ONeill, L.A.
    IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65 (2006), J. Biol. Chem., 281, 34973-34981.
    View publication on PubMed
Search for more literature for 2.7.11.10

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged wild-type and mutant enzymes in HEK-293 and HeLa cells, expression of the C-terminal fragment, comprising amino acids 541-716, of IKKepsilon with NF-kappaB2/p100/p52 in yeast two-hybrid cells Mus musculus

Protein Variants

Protein Variants Comment Organism
K38A inactive IKKepsilon mutant Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein p100 Mus musculus interaction with the NF-kappaB complex ADP + phosphorylated protein p100
-
 ?
ATP + protein p165 Mus musculus p65 is part of the IKKepsilon complex with p25, interaction with the NF-kappaB complex ADP + phosphorylated protein p165
-
 ?
additional information Mus musculus IKKepsilon is important in the regulation of the alternative NF-kappaB activation pathway involving p52 and p65, IKKepsilon interacts with p52 and promotes transactivation via p65 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein p100 interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p100
-
 ?
ATP + protein p100 required for the interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p100
-
 ?
ATP + protein p165 p65 is part of the IKKepsilon complex with p25, interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p165
-
 ?
ATP + protein p165 required for the interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p165
-
 ?
additional information IKKepsilon is important in the regulation of the alternative NF-kappaB activation pathway involving p52 and p65, IKKepsilon interacts with p52 and promotes transactivation via p65 Mus musculus ?
-
 ?
additional information interaction analysis of IKKepsilon with NF-kappaB complex components/p25/p65 by immunoprecipitation and mass spectrometric analysis, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
IKKepsilon
-
 Mus musculus
non-canonical IkappaBkinase epsilon
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus