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Literature summary for 2.7.11.10 extracted from

  • Gloire, G.; Dejardin, E.; Piette, J.
    Extending the nuclear roles of IkappaB kinase subunits (2006), Biochem. Pharmacol., 72, 1081-1089.
    View publication on PubMed
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
cdc37 the chaperone protein associates with the IKK complex and is required for its TNFalpha-induced activation Mus musculus
HSP70 the chaperone protein associates with the IKK complex and is required for its TNFalpha-induced activation Mus musculus
Hsp90 the chaperone protein associates with the IKK complex and is required for its TNFalpha-induced activation Mus musculus
additional information the IkappaB complex gets activated by phosphorylation, the enzyme activity is induced by proinflammatory cytokines and by oxidative and genotoxic stress, mechanisms/pathways of activation and derepression of the IKK complex, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information fibroblasts of ikkbeta-/- mice exhibit enhanced apoptosis in response to TNFalpha, NEMO/IKKgamma-deficient mice shows a phenotype with liver damage, but can be rescued by inactivation of the gene encoding the tumor necrosis factor-1, phenotypes, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm IKKbeta and IKKalpha are almost entirely cytoplasmic, IKK complex component scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, shuttles between the cytoplasm and the nucleus in a CRM-dependent manner Mus musculus 5737
-
nucleus IKK complex component scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, shuttles between the cytoplasm and the nucleus in a CRM-dependent manner Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + IkappaB protein Mus musculus the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages ADP + phosphorylated IkappaB
-
 ?
additional information Mus musculus mechanisms/pathways of activation and derepression of the IKK complex, regulation, detailed overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the IkappaB complex gets activated by phosphorylation and then autophosphorylates IkappaBalpha at Ser32 and Ser36 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-
liver
-
 Mus musculus
-
macrophage
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-
RAW-264.7 cell macrophage cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IkappaB protein the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages Mus musculus ADP + phosphorylated IkappaB
-
 ?
ATP + IkappaBalpha phosphorylation of IkappaBalpha at Ser32 and Ser36 Mus musculus ADP + phosphorylated IkappaBalpha
-
 ?
ATP + IkappaBbeta phosphorylation of IkappaBalpha at Ser19 and Ser23 Mus musculus ADP + phosphorylated IkappaBbeta
-
 ?
additional information mechanisms/pathways of activation and derepression of the IKK complex, regulation, detailed overview Mus musculus ?
-
 ?
additional information the enzyme activity is included in a complex formed of the scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, and the Ikkalpha and IKKbeta kinases, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
More the enzyme activity is included in a complex formed of the scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, and the Ikkalpha and IKKbeta kinases, overview, the complex contains a zinc finger-like domain, N- and C-terminal coiled-coil domains, two alpha-helices and a leucine zipper Mus musculus

Synonyms

Synonyms Comment Organism
IkappaB-kinase
-
 Mus musculus
IKK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus