Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | IKKgamma phosphorylation by IKKbeta is induced by the cytokine TNFalpha and the viral oncoprotein Tax | Homo sapiens | |
NEMO | i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma and ubiquination, involving the zinc finger of NEMO and c-IAP1, are required for activation of the IkappaB kinase complex by inflammatory stimuli such as tumor necrosis factor TNFalpha | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
coexpression of FLAG-tagged IKKbeta, T7-tagged IKKgamma, and Tax in 293T cells and in murine embryonic fibroblasts devoid of the enzyme | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutations of X-linked gene encoding IKKgamma can lead to immunodeficiency diseases interfering with NFkappaB-signaling | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | IKK marks cytoplasmic NFkappaB inhibitors for proteolytic destruction playing a role in regulation of genetic cell cycle programs, IKK regulates nuclear translocation of transcription factor NFkappaB | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
IKK-1 and IKK-2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | subunit IKKgamma is activated by phosphorylation via IKKbeta subunit at Ser31, Ser43, and Ser376, IKKgamma phosphorylation requires its zinc finger sequence at the C-terminus, phosphopeptide mapping | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein] | activation and reaction mechanism | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [GST-IkappaBalpha protein] | - |
Homo sapiens | ADP + [GST-IkappaBalpha phosphoprotein] | - |
? | |
additional information | IKK marks cytoplasmic NFkappaB inhibitors for proteolytic destruction playing a role in regulation of genetic cell cycle programs, IKK regulates nuclear translocation of transcription factor NFkappaB | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |