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Literature summary for 2.7.11.1 extracted from

  • Lv, Y.; Chen, J.; Hu, J.; Qian, Y.; Kong, Y.; Fu, L.
    Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the Rho-associated kinase 1/myosin light chains/actin pathway (2020), Front. Pharmacol., 11, 598592 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Mus musculus the enzyme (ROCK1) is a key regulator of actin cytoskeleton and cell polarity. ROCK1 directly induces the phosphorylation of myosin light chains (MLC) or inactivates the phosphorylated myosin phosphatase-binding subunit (MYPT), thereby directly or indirectly increases MLC phosphorylation ADP + phosphorylated myosin light chain
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
microglia
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
 Mus musculus ADP + phosphorylated myosin light chain
-
 ?
ATP + myosin light chain the enzyme (ROCK1) is a key regulator of actin cytoskeleton and cell polarity. ROCK1 directly induces the phosphorylation of myosin light chains (MLC) or inactivates the phosphorylated myosin phosphatase-binding subunit (MYPT), thereby directly or indirectly increases MLC phosphorylation Mus musculus ADP + phosphorylated myosin light chain
-
 ?

Synonyms

Synonyms Comment Organism
Rho-associated kinase 1
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 Mus musculus
ROCK1
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 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme (ROCK1) is a key regulator of actin cytoskeleton and cell polarity. ROCK1 directly induces the phosphorylation of myosin light chains (MLC) or inactivates the phosphorylated myosin phosphatase-binding subunit (MYPT), thereby directly or indirectly increases MLC phosphorylation. The ROCK1/MLC/actin pathway regulated by nonmuscle myosin heavy chain IIA (NMMHC IIA) might be a potential mechanism for exosome release. NMMHC IIA might affect the release of exosomes by triggering the ROCK1/MLC/actin signaling pathway Mus musculus