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Literature summary for 2.7.11.1 extracted from

  • Roach, B.; Ngo, J.; Limso, C.; Oloja, K.; Bhandari, D.
    Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5 (2018), Biochem. Biophys. Res. Commun., 504, 753-758.
    View publication on PubMed
Search for more literature for 2.7.11.1

Protein Variants

Protein Variants Comment Organism
S47D the mutant enzyme inhibits cell migration and promotes cell proliferation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q00535
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the phosphoregulatory site S47 abolishes CDK5-p35 binding and renders the kinase catalytically inactive Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + p35
-
 Homo sapiens ADP + phosphorylated p35
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Homo sapiens
cyclin-dependent kinase 5
-
 Homo sapiens

General Information

General Information Comment Organism
evolution S47 in CDK5 is evolutionarily conserved with a serine at this position in human, bovine, rat, mouse and Drosophila CDK5 and a substitution with threonine in yeast Homo sapiens
malfunction overactivation of the enzyme (CDK5) has been implicated in several pathologies including neurodegeneration, cancer cell metastasis and type II diabetes Homo sapiens
physiological function the enzyme (CDK5) is essential for embryonic development Homo sapiens