Cloned (Comment) | Organism |
---|---|
transient expression of HA-tagged wild-type and mutant enzymes in CHO cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S9A | site-directed mutagenesis, mutant cannot be inhibited by phosphorylation at position 9 and is thus constitutively active | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation of GSK3beta at S9 inhibits the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Homo sapiens | 5874 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Homo sapiens | - |
ADP + O-phospho-[tau-protein] | - |
? | |
additional information | Homo sapiens | phosphorylated tau is important in cytoskeleton assembly | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of GSK3beta at S9 inhibits the enzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | - |
Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | phosphorylation at the C-terminus, lower activity with C-terminally truncated tau D421 compared to the wild-type tau, the truncated tau protein forms sarcosyl-insoluble aggregates | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | phosphorylated tau is important in cytoskeleton assembly | Homo sapiens | ? | - |
? | |
additional information | GSK3beta catalyzes tau phosphorylation, EC 2.7.11.26, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase 3beta | - |
Homo sapiens |
GSK3beta | - |
Homo sapiens |
More | see also EC 2.7.11.26 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |