Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E864K | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
G831R | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
G935R | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I. Mutant retains kinase activity exceeding 130 microM JAK inhibitor-I | Homo sapiens |
M929I | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
N909K | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
P1057S | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
R1127K | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
R975G | mutation is sufficient to support growth and downstream signaling at high oncentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
V881A | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
Y918H | mutation is sufficient to support growth and downstream signaling at high concentrations of 2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, i.e. JAK inhibitor-I | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(1,1-dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one | i.e. JAK inhibitor-I | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
JAK2 | - |
Homo sapiens |