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Literature summary for 2.7.1.74 extracted from

  • Zhong, R.; Liang, B.; Xin, R.; Zhu, X.; Liu, Z.; Chen, Q.; Hou, Y.; Jin, Z.; Qi, M.; Ma, S.; Liu, X.
    Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells (2018), Int. J. Oncol., 52, 1000-1010 .
    View publication on PubMed
Search for more literature for 2.7.1.74

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is activated in response to ionizing radiation Homo sapiens

Protein Variants

Protein Variants Comment Organism
S74A the mutation abrogates phosphorylation of the protein Homo sapiens
S74E the mutation mimics phosphorylation of the protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + deoxycytidine Homo sapiens
-
 NDP + dCMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27707
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the phosphorylated and activated enzyme inhibits IR-induced total cell death and apoptosis, and promotes ionizing radiation-induced autophagy through the phospho-mammalian target of rapamycin pathway and by inhibiting the binding of Bcl-2 protein to Bcl-2/Beclin1 Homo sapiens