KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
uridine | pH 7.6, 37°C, ovarian carcinoma | Homo sapiens | |
0.8 | - |
ATP | pH 7.6, 37°C, normal liver | Rattus norvegicus | |
0.8 | - |
uridine | pH 7.6, 37°C, normal liver | Rattus norvegicus | |
5 | - |
ATP | pH 7.6, 37°C, hepatoma cells | Rattus norvegicus | |
5 | - |
uridine | pH 7.6, 37°C, hepatoma cells | Rattus norvegicus | |
11.5 | - |
uridine | pH 7.6, 37°C, normal ovary | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | 36% of liver activity | Rattus norvegicus | - |
bone marrow | 184% of liver activity | Rattus norvegicus | - |
brain | 248% of liver activity | Rattus norvegicus | - |
heart | 85% of liver activity | Rattus norvegicus | - |
hepatoma cell | hepatoma 3924A cells, 2fold increase in activity during early log phase of prolifration | Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
lung | 142% of liver activity | Rattus norvegicus | - |
ovarian cancer cell | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
renal cortex | 160% of liver activity | Rattus norvegicus | - |
skeletal muscle | 95% of liver activity | Rattus norvegicus | - |
spleen | 212% of liver activity | Rattus norvegicus | - |
testis | 140% of liver activity | Rattus norvegicus | - |
thymus | 468% of liver activity | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
in hepatomas of slow and intermediate growth rates, uridine kinase activity increases 1.5-2.6fold, in hepatomas of rapid growth rates activity increases 5-6fold over that in normal livers | Rattus norvegicus |
additional information | - |
5-13fold increase of uridine kinase activity in ovarian carcinomas over the activity in normal ovaries | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + uridine | - |
Rattus norvegicus | ADP + UMP | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | 7.6 | normal liver and hepatoma cells | Rattus norvegicus |