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Literature summary for 2.7.1.229 extracted from

  • Tourneux, L.; Bucurenci, N.; Saveanu, C.; Kaminski, P.A.; Bouzon, M.; Pistotnik, E.; Namane, A.; Marliere, P.; Barzu, O.; Li De La Sierra, I.; Neuhard, J.; Gilles, A.M.
    Genetic and biochemical characterization of Salmonella enterica serovar Typhi deoxyribokinase (2000), J. Bacteriol., 182, 869-873 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Salmonella enterica subsp. enterica serovar Typhi

Protein Variants

Protein Variants Comment Organism
M10N mutation to the coresponding residue of ribokinase, decreases the Vmax of deoxyribokinase by a factor of 2.5 and increases the Km for deoxyribose by a factor of 70, compared to the parent enzyme Salmonella enterica subsp. enterica serovar Typhi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 2-deoxy-D-ribose wild-type, pH 7.4, 30°C Salmonella enterica subsp. enterica serovar Typhi
2
-
 D-ribose wild-type, pH 7.4, 30°C Salmonella enterica subsp. enterica serovar Typhi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2-deoxy-D-ribose Salmonella enterica subsp. enterica serovar Typhi
-
 ADP + 2-deoxy-D-ribose 5-phosphate
-
 ?
ATP + 2-deoxy-D-ribose Salmonella enterica subsp. enterica serovar Typhi Ty2
-
 ADP + 2-deoxy-D-ribose 5-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhi
-
-
-
Salmonella enterica subsp. enterica serovar Typhi Ty2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-deoxy-D-ribose
-
 Salmonella enterica subsp. enterica serovar Typhi ADP + 2-deoxy-D-ribose 5-phosphate
-
 ?
ATP + 2-deoxy-D-ribose
-
 Salmonella enterica subsp. enterica serovar Typhi Ty2 ADP + 2-deoxy-D-ribose 5-phosphate
-
 ?
ATP + D-ribose
-
 Salmonella enterica subsp. enterica serovar Typhi ADP + D-ribose 5-phosphate
-
 ?
ATP + D-ribose
-
 Salmonella enterica subsp. enterica serovar Typhi Ty2 ADP + D-ribose 5-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 33228, mass spectrometry, x * 33229, calulated from sequence Salmonella enterica subsp. enterica serovar Typhi