BRENDA - Enzyme Database show
show all sequences of 2.7.1.165

D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK)

Sass, J.O.; Fischer, K.; Wang, R.; Christensen, E.; Scholl-Buergi, S.; Chang, R.; Kapelari, K.; Walter, M.; Hum. Mutat. 31, 1280-1285 (2010)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in HEK-293 cells
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
F483S
the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia
Homo sapiens
F493C
the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia
Homo sapiens
L510C
the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
blood plasma
-
Homo sapiens
-
urine
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-glycerate
-
722379
Homo sapiens
ADP + 2-phospho-D-glycerate
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in HEK-293 cells
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
F483S
the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia
Homo sapiens
F493C
the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia
Homo sapiens
L510C
the mutant shows loss of enzyme activity. The mutation leads to D-glyceric acidemia
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
blood plasma
-
Homo sapiens
-
urine
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-glycerate
-
722379
Homo sapiens
ADP + 2-phospho-D-glycerate
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase
Homo sapiens
Other publictions for EC 2.7.1.165
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739276
Keech
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739413
Zelcbuch
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1
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722379
Sass
D-glyceric aciduria is caused ...
Homo sapiens
Hum. Mutat.
31
1280-1285
2010
-
-
1
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3
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2
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1
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1
1
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-
696906
Liu
A MOFRL family glycerate kinas ...
Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7
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8
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20
1
1
1
1
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1
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1
1
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1
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13
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8
2
2
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1
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20
1
1
1
1
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1
1
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686769
Bartsch
Only plant-type (GLYK) glycera ...
Escherichia coli K-12, Synechocystis sp.
FEBS Lett.
582
3025-3028
2008
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672800
Kehrer
Glycerate kinase of the hypert ...
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2007
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3
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3
2
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685823
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Thermoproteus tenax
BMC Genomics
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2007
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7
1
1
1
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2
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672720
Noh
-
Purification and characterizat ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2, Thermoplasma acidophilum
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11
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3
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5
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42
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1
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5
1
3
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4
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2
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4
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673730
Reher
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749246
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5083
Hubbard
Evolution of enzymatic activit ...
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Hyphomicrobium methylovorum
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641336
Hill
The purification of glycerate ...
Hyphomicrobium sp., Pseudomonas sp.
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