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Literature summary for 2.7.1.154 extracted from

  • Zhuo, M.Q.; Pan, Y.X.; Wu, K.; Xu, Y.H.; Luo, Z.
    Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco (2017), Gen. Comp. Endocrinol., 247, 34-45 .
    View publication on PubMed
Search for more literature for 2.7.1.154

Cloned(Commentary)

Cloned (Comment) Organism
gene PI3KC2a, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis. PI3K enzyme sequence comparisons Tachysurus fulvidraco
gene PI3KC2b, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis, PI3K enzyme sequence comparisons Tachysurus fulvidraco

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin
-
 Tachysurus fulvidraco

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Tachysurus fulvidraco

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Tachysurus fulvidraco
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Tachysurus fulvidraco A0A2I4KAQ4
-
-
Tachysurus fulvidraco A0A2I4KAQ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Tachysurus fulvidraco
-
liver
-
 Tachysurus fulvidraco
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Tachysurus fulvidraco ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
 ?

Subunits

Subunits Comment Organism
More the class II PI3Ks contain a ras-binding domain, a N-C2 domain, a PIK domain, a catalytic domain, a Phox-homology domain, and a C-C2 domain Tachysurus fulvidraco

Synonyms

Synonyms Comment Organism
class II PI3K
-
 Tachysurus fulvidraco
PI3KC2a
-
 Tachysurus fulvidraco
PI3KC2b
-
 Tachysurus fulvidraco

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Tachysurus fulvidraco

Expression

Organism Comment Expression
Tachysurus fulvidraco PI3KCb and PI3KC2a mRNA levels are significantly lower in insulin/wortmannin group than those in single insulin group. Single wortmannin treatment shows no differences on the mRNA level of all PI3Ks, but wortmannin pretreatment significantly reduces insulin-induced upregulation on the mRNA level of PI3KCb and PI3KC2a down
Tachysurus fulvidraco PI3KCb and PI3KC2a mRNA levels are significantly lower in insulin/wortmannin group than those in single insulin group. Single wortmannin treatment shows no differences on the mRNA level of all PI3Ks, but wortmannin pretreatment significantly reduces insulin-induced upregulation on the mRNA level of PI3KCb and PI3KC2a in insulin/wortmannin group than those in single insulin group down
Tachysurus fulvidraco insulin incubation also significantly upregulates the mRNA expression of PI3KCb and PI3KC2a up

General Information

General Information Comment Organism
evolution PI3K enzyme sequence comparisons Tachysurus fulvidraco
malfunction PI3KCb and PI3KC2a mRNA levels re significantly lower in insulin + wortmannin group than those in single insulin group Tachysurus fulvidraco
metabolism insulin treatment shows no significant effect on GDH activity and mRNA expression of PI3KCa, PI3KCd, PI3KCg, PI3KC2b, PI3KC3 and eEF2 both in the in vivo and in vitro studies. Among seven PI3K members, PI3KCb and PI3KC2a are more sensitive to the insulin signaling pathway, and insulin stimulates hepatic protein synthesis in yellow catfish through PI3K signaling pathway Tachysurus fulvidraco