Cloned (Comment) | Organism |
---|---|
PI5P4Kalpha is predominantly in the cytoplasm, principally cytosolic, when recombinantly expressed | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | recombinantly expressed PI5P4Kalpha | Mammalia | 5829 | - |
membrane | PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus | Mammalia | 16020 | - |
additional information | analysis of subcellular localization of native and recombinant isozyme PI5P4Kalpha, overview | Mammalia | - |
- |
nucleus | PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus | Mammalia | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | Mammalia | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DT-40 cell | - |
Mammalia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate | - |
Mammalia | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 5-phosphate 4-kinase | - |
Mammalia |
PI5P4K | - |
Mammalia |
PI5P4Kalpha | - |
Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mammalia |
General Information | Comment | Organism |
---|---|---|
evolution | PI5P4Kalpha is present in all vertebrates, and a few organisms are missing either beta or gamma. Several key structural differences between the three mammalian PI5P4Ks largely account for their different activities, e.g. a glycine-rich loop supposed to be involved with substrate interaction | Mammalia |