Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enhanced inositol 1,4,5-trisphosphate 3-kinase A in the synaptic field by long-term potentiation induction in rat hippocampal neurons | Mus musculus | |
additional information | enhanced IP3K-A IR in the synaptic field by long-term potentiation induction in rat hippocampal neurons | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
generation of knock-out mice | Mus musculus |
generation of knock-out rats and point mutant, IP3K-A is overexpressed in DIV 22 hippocampal neurons by infection with adenovirus containing full-length IP3K-A | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
K262A | the green fluorescent protein-inositol 1,4,5-trisphosphate 3-kinase A point mutant is generated by site-directed mutagenesis, point mutant lacks kinase activity | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus | |
Ca2+ | IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus | reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | P17105 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
dendritic cell | - |
Mus musculus | - |
hippocampal cell line | - |
Rattus norvegicus | - |
neuron | - |
Mus musculus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling | Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | reducing the influx of calcium released from endoplasmic reticulum via IP3 receptor signaling | Rattus norvegicus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol 1,4,5-trisphosphate 3-kinase A | - |
Mus musculus |
inositol 1,4,5-trisphosphate 3-kinase A | - |
Rattus norvegicus |
IP3K-A | - |
Mus musculus |
IP3K-A | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | overexpression of IP3K-A in DIV 22 hippocampal neurons by infection with adenovirus containing full-length inositol 1,4,5-trisphosphate 3-kinase A leads to a markedly increased number of dendritic structure 18 h after infection, overexpressed GFP-IP3K-A signals are highly localized in the heads of dendritic protrusions | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knock-out mice show deficits of synaptic plasticity in perforant path and in hippocampal-dependent memory performances | Mus musculus |
physiological function | on neural activation, inositol 1,4,5-trisphosphate 3-kinase A binds directly to activated Rac1 and recruits it to the actin cytoskeleton in the postsynaptic area, enzyme is critical for the spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism, inositol 1,4,5-trisphosphate 3-kinase A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus |
physiological function | on neural activation, inositol 1,4,5-trisphosphate 3-kinase A binds directly to activated Rac1 and recruits it to the actin cytoskeleton in the postsynaptic area, enzyme is critical for the spatial and temporal regulation of spine actin remodeling, synaptic plasticity, and learning and memory via an activity-dependent Rac scaffolding mechanism, inositol 1,4,5-trisphosphate 3-kinase A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus |