Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EGTA | Ca2+/calmodulin-activated enzyme | Xenopus laevis | |
KN-62 | calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation | Xenopus laevis | |
KN-93 | calmodulin-dependent protein kinase II inhibitor; prevents the Ca2+/calmodulin-mediated activation | Xenopus laevis | |
RS-20 | calmodulin antagonist, prevents the Ca2+/calmodulin-mediated activation | Xenopus laevis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Xenopus laevis | 5829 | - |
soluble | - |
Xenopus laevis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation is mediated by calmodulin and the calmodulin-dependent protein kinase II | Xenopus laevis | |
Ca2+ | activation by Ca2+/calmodulin | Xenopus laevis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Xenopus laevis | involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Xenopus laevis | involved in inositol polyphosphate metabolism | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | - |
adult | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Xenopus laevis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Xenopus laevis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Xenopus laevis | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | involvement of a calmodulin-dependent protein kinase II-mediated phosphorylation in enzyme regulation, enzyme decreases the Ins(1,4,5)P3 concentration, this second messenger binds to the InsP3 receptor to release Ca2+ from intracellular stores, the activation of enzyme may be involved in the Ca2+-dependent down regulation of the InsP3-mediated Ca2+ release, enzyme may play a key role in regulating signals arising from the phospholipase C-related transduction system | Xenopus laevis | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | involved in inositol polyphosphate metabolism | Xenopus laevis | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Xenopus laevis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Xenopus laevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Xenopus laevis | |
Calmodulin | activation by Ca2+/calmodulin | Xenopus laevis | |
Calmodulin | mediates activation by Ca2+ | Xenopus laevis |