Activating Compound | Comment | Organism | Structure |
---|---|---|---|
omega-Methylpyridoxal phosphate | can replace pyridoxal phosphate, Km: 0.004 mM | Neurospora sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Co2+ | 0.004 M, 80% inhibition | Neurospora sp. | |
Cu2+ | 0.004 M, 80% inhibition | Neurospora sp. | |
hydroxylamine | 0.004 M, 80% inhibition | Neurospora sp. | |
iodoacetate | 0.004 M, 95% inhibition | Neurospora sp. | |
Semicarbazide | 0.004 M, 80% inhibition | Neurospora sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.1 | - |
L-histidinol phosphate | pH 8.1, 37°C | Neurospora sp. | |
1.2 | - |
2-oxoglutarate | pH 8.1, 37°C | Neurospora sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neurospora sp. | - |
C141-T1710, C84, C141 | - |
Purification (Comment) | Organism |
---|---|
C141-T1710, C141 | Neurospora sp. |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
60.3 | - |
- |
Neurospora sp. |
Storage Stability | Organism |
---|---|
-20°C, stable for several months | Neurospora sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-2-aminoadipate | 40% of the activity with L-glutamate | Neurospora sp. | L-histidinol phosphate + 2-oxoadipate | - |
r | |
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-arginine | 33% of the activity with L-glutamate | Neurospora sp. | L-histidinol phosphate + 2-oxo-5-guanidinopentanoate | - |
r | |
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamine | 4% of the activity with L-glutamate | Neurospora sp. | L-histidinol phosphate + 4-carbamoyl-2-oxobutanoate | - |
r | |
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-histidine | 30% of the activity with L-glutamate | Neurospora sp. | L-histidinol phosphate + 3-(1H-imidazol-4-yl)-2-oxopropanoate | - |
r | |
L-histidinol phosphate + 2-oxo-5-guanidinopentanoate | - |
Neurospora sp. | 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-arginine | - |
r | |
L-histidinol phosphate + 2-oxoadipate | 70% of the activity with 2-oxoglutarate | Neurospora sp. | 3-(imidazol-4-yl)-2-oxopropyl phosphate + 2-aminoadipate | - |
r | |
L-histidinol phosphate + 2-oxoglutarate | - |
Neurospora sp. | 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Glu | i.e. imidazoleacetol phosphate + L-Glu | r | |
additional information | no substrate: oxaloacetate, pyruvate | Neurospora sp. | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Neurospora sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.1 | - |
diphosphate buffer | Neurospora sp. |
8.4 | - |
diethanolamine buffer | Neurospora sp. |
8.5 | - |
triethanolamine buffer | Neurospora sp. |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9 | pH 7.5: about 85% of activity maximum, pH 9.0: about 50% of activity maximum, diphosphate buffer | Neurospora sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | Km: 0.0012 mM | Neurospora sp. | |
pyridoxal 5'-phosphate | a pyridoxal phosphate protein | Neurospora sp. |